Mouse Models for Cancer Immunotherapy Research.
Document Type
Article
Publication Date
11-2018
Keywords
JMG
JAX Source
Cancer Discov 2018 Nov; 8(11):1358-1365
Volume
8
Issue
11
First Page
1358
Last Page
1365
ISSN
2159-8290
PMID
30309862
DOI
https://doi.org/10.1158/2159-8290.CD-18-0044
Abstract
Immunotherapy has revolutionized cancer therapy, largely attributed to the success of immune-checkpoint blockade. However, there are subsets of patients across multiple cancers who have not shown robust responses to these agents. A major impediment to progress in the field is the availability of faithful mouse models that recapitulate the complexity of human malignancy and immune contexture within the tumor microenvironment. These models are urgently needed across all malignancies to interrogate and predict antitumor immune responses and therapeutic efficacy in clinical trials. Herein, we seek to review pros and cons of different cancer mouse models, and how they can be used as platforms to predict efficacy and resistance to cancer immunotherapies.
Recommended Citation
Olson B,
Li Y,
Lin Y,
Liu E,
Patnaik A.
Mouse Models for Cancer Immunotherapy Research. Cancer Discov 2018 Nov; 8(11):1358-1365