Document Type
Article
Publication Date
3-6-2018
JAX Source
Cell Rep 2018 Mar 6; 22(10):2667-2676.
Volume
22
Issue
10
First Page
2667
Last Page
2676
ISSN
2211-1247
PMID
29514095
DOI
https://doi.org/10.1016/j.celrep.2018.02.032
Abstract
Many patients with type 1 diabetes (T1D) have residual β cells producing small amounts of C-peptide long after disease onset but develop an inadequate glucagon response to hypoglycemia following T1D diagnosis. The features of these residual β cells and α cells in the islet endocrine compartment are largely unknown, due to the difficulty of comprehensive investigation. By studying the T1D pancreas and isolated islets, we show that remnant β cells appeared to maintain several aspects of regulated insulin secretion. However, the function of T1D α cells was markedly reduced, and these cells had alterations in transcription factors constituting α and β cell identity. In the native pancreas and after placing the T1D islets into a non-autoimmune, normoglycemic in vivo environment, there was no evidence of α-to-β cell conversion. These results suggest an explanation for the disordered T1D counterregulatory glucagon response to hypoglycemia. Cell Rep 2018 Mar 6; 22(10):2667-2676.
Recommended Citation
Brissova, Marcela; Haliyur, Rachana; Saunders, Diane; Shrestha, Shristi; Dai, Chunhua; Blodgett, David M; Bottino, Rita; Campbell-Thompson, Martha; Aramandla, Radhika; Poffenberger, Gregory; Lindner, Jill; Pan, Fong Cheng; von Herrath, Matthias G; Greiner, Dale L; Shultz, Leonard D.; Sanyoura, May; Philipson, Louis H; Atkinson, Mark; Harlan, David M; Levy, Shawn E; Prasad, Nripesh; Stein, Roland; and Powers, Alvin C, "α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes." (2018). Faculty Research 2018. 55.
https://mouseion.jax.org/stfb2018/55
Comments
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).