Title

Integrative Personal Omics Profiles during Periods of Weight Gain and Loss.

Document Type

Article

Publication Date

2-28-2018

JAX Source

Cell Syst 2018 Feb 28; 6(2):157-170.e8

PMID

29361466

DOI

https://doi.org/10.1016/j.cels.2017.12.013

Grant

DE02378901

Abstract

Advances in omics technologies now allow an unprecedented level of phenotyping for human diseases, including obesity, in which individual responses to excess weight are heterogeneous and unpredictable. To aid the development of better understanding of these phenotypes, we performed a controlled longitudinal weight perturbation study combining multiple omics strategies (genomics, transcriptomics, multiple proteomics assays, metabolomics, and microbiomics) during periods of weight gain and loss in humans. Results demonstrated that: (1) weight gain is associated with the activation of strong inflammatory and hypertrophic cardiomyopathy signatures in blood; (2) although weight loss reverses some changes, a number of signatures persist, indicative of long-term physiologic changes; (3) we observed omics signatures associated with insulin resistance that may serve as novel diagnostics; (4) specific biomolecules were highly individualized and stable in response to perturbations, potentially representing stable personalized markers. Most data are available open access and serve as a valuable resource for the community. Cell Syst 2018 Feb 28; 6(2):157-170.e8.

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