Document Type

Article

Publication Date

2-16-2018

JAX Source

NPJ Regen Med 2018 Feb 16; 3:4

PMID

29479480

DOI

https://doi.org/10.1038/s41536-018-0045-4

Abstract

Duchenne muscular dystrophy (DMD) is a common fatal heritable myopathy, with cardiorespiratory failure occurring by the third decade of life. There is no specific treatment for DMD cardiomyopathy, in large part due to a lack of understanding of the mechanisms underlying the cardiac failure. Mdx mice, which have the same dystrophin mutation as human patients, are of limited use, as they do not develop early dilated cardiomyopathy as seen in patients. Here we summarize the usefulness of the various commonly used DMD mouse models, highlight a model with shortened telomeres like humans, and identify directions that warrant further investigation. NPJ Regen Med 2018 Feb 16; 3:4.

Comments

Open access under Creative Commons Attribution (CC BY) license (Creative Commons Attribution 4.0 International License).

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