Document Type
Article
Publication Date
2-16-2018
JAX Source
NPJ Regen Med 2018 Feb 16; 3:4
Volume
3
First Page
4
Last Page
4
ISSN
2057-3995
PMID
29479480
DOI
https://doi.org/10.1038/s41536-018-0045-4
Abstract
Duchenne muscular dystrophy (DMD) is a common fatal heritable myopathy, with cardiorespiratory failure occurring by the third decade of life. There is no specific treatment for DMD cardiomyopathy, in large part due to a lack of understanding of the mechanisms underlying the cardiac failure. Mdx mice, which have the same dystrophin mutation as human patients, are of limited use, as they do not develop early dilated cardiomyopathy as seen in patients. Here we summarize the usefulness of the various commonly used DMD mouse models, highlight a model with shortened telomeres like humans, and identify directions that warrant further investigation. NPJ Regen Med 2018 Feb 16; 3:4.
Recommended Citation
Yucel N,
Chang A,
Day J,
Rosenthal N,
Blau H.
Humanizing the mdx mouse model of DMD: the long and the short of it. NPJ Regen Med 2018 Feb 16; 3:4
Comments
Open access under Creative Commons Attribution (CC BY) license (Creative Commons Attribution 4.0 International License).