Document Type

Article

Publication Date

3-26-2018

JAX Source

Diabetes Metab Syndr Obes 2018 Mar 26; 11:65-84.

PMID

29618935

Abstract

Background: Follistatin (Fst) promotes brown adipocyte characteristics in adipose tissues.

Methods: Abdominal fat volume (CT scan), glucose clearance (GTT test), and metabolomics analysis (mass spectrometry) of adipose tissues from Fst transgenic (Fst-Tg) and wild type (WT) control mice were analyzed. Oxygen consumption (Seahorse Analyzer) and lipidomics (gas chromatography) was analyzed in 3T3-L1 cells.

Results: Fst-Tg mice show significant decrease in abdominal fat content, increased glucose clearance, improved plasma lipid profiles and significant changes in several conventional metabolites compared to the WT mice. Furthermore, overexpression of Fst in 3T3-L1 cells resulted in up regulation of key brown/beige markers and changes in lipidomics profiles.

Conclusion: Fst modulates key factors involved in promoting metabolic syndrome and could be used for therapeutic intervention.

Diabetes Metab Syndr Obes 2018 Mar 26; 11:65-84.

Comments

This is an open access article under a Creative Commons Attribution 3.0 License.

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