Document Type
Article
Publication Date
3-26-2018
JAX Source
Diabetes Metab Syndr Obes 2018 Mar 26; 11:65-84.
Volume
11
First Page
65
Last Page
84
ISSN
1178-7007
PMID
29618935
Abstract
Background: Follistatin (Fst) promotes brown adipocyte characteristics in adipose tissues.
Methods: Abdominal fat volume (CT scan), glucose clearance (GTT test), and metabolomics analysis (mass spectrometry) of adipose tissues from Fst transgenic (Fst-Tg) and wild type (WT) control mice were analyzed. Oxygen consumption (Seahorse Analyzer) and lipidomics (gas chromatography) was analyzed in 3T3-L1 cells.
Results: Fst-Tg mice show significant decrease in abdominal fat content, increased glucose clearance, improved plasma lipid profiles and significant changes in several conventional metabolites compared to the WT mice. Furthermore, overexpression of Fst in 3T3-L1 cells resulted in up regulation of key brown/beige markers and changes in lipidomics profiles.
Conclusion: Fst modulates key factors involved in promoting metabolic syndrome and could be used for therapeutic intervention.
Diabetes Metab Syndr Obes 2018 Mar 26; 11:65-84.
Recommended Citation
Singh R,
Pervin S,
Lee S,
Kuo A,
Grijalva V,
David J,
Vergnes L,
Reddy S.
Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases. Diabetes Metab Syndr Obes 2018 Mar 26; 11:65-84.
Comments
This is an open access article under a Creative Commons Attribution 3.0 License.