Histone methyltransferase PRDM9 is not essential for meiosis in male mice.
Document Type
Article
Publication Date
7-2019
Keywords
JMG
JAX Source
Genome Res 2019 Jul; 29(7):1078-1086
Volume
29
Issue
7
First Page
1078
Last Page
1086
ISSN
1549-5469
PMID
31186301
DOI
https://doi.org/10.1101/gr.244426.118
Grant
GM099640,GM078452
Abstract
A hallmark of meiosis is the rearrangement of parental alleles to ensure genetic diversity in the gametes. These chromosome rearrangements are mediated by the repair of programmed DNA double-strand breaks (DSBs) as genetic crossovers between parental homologs. In mice, humans, and many other mammals, meiotic DSBs occur primarily at hotspots, determined by sequence-specific binding of the PRDM9 protein. Without PRDM9, meiotic DSBs occur near gene promoters and other functional sites. Studies in a limited number of mouse strains showed that functional PRDM9 is required to complete meiosis, but despite its apparent importance,
Recommended Citation
Mihola O,
Pratto F,
Brick K,
Linhartova E,
Kobets T,
Flachs P,
Baker CL,
Sedlacek R,
Paigen K,
Petkov PM,
Camerini-Otero R,
Trachtulec Z.
Histone methyltransferase PRDM9 is not essential for meiosis in male mice. Genome Res 2019 Jul; 29(7):1078-1086