IL-10-Dependent Crosstalk between Murine Marginal Zone B Cells, Macrophages, and CD8α

Document Type

Article

Publication Date

7-16-2019

Keywords

JGM

JAX Source

Immunity 2019 Jul 16; 51(1):64-76.e7

Volume

51

Issue

1

First Page

64

Last Page

76

ISSN

1097-4180

PMID

31231033

DOI

https://doi.org/10.1016/j.immuni.2019.05.011

Grant

AI133440

Abstract

Type 1 CD8α+ conventional dendritic cells (cDC1s) are required for CD8+ T cell priming but, paradoxically, promote splenic Listeria monocytogenes infection. Using mice with impaired cDC2 function, we ruled out a role for cDC2s in this process and instead discovered an interleukin-10 (IL-10)-dependent cellular crosstalk in the marginal zone (MZ) that promoted bacterial infection. Mice lacking the guanine nucleotide exchange factor DOCK8 or CD19 lost IL-10-producing MZ B cells and were resistant to Listeria. IL-10 increased intracellular Listeria in cDC1s indirectly by reducing inducible nitric oxide synthase expression early after infection and increasing intracellular Listeria in MZ metallophilic macrophages (MMMs). These MMMs trans-infected cDC1s, which, in turn, transported Listeria into the white pulp to prime CD8+ T cells. However, this also facilitated bacterial expansion. Therefore, IL-10-mediated crosstalk between B cells, macrophages, and cDC1s in the MZ promotes both Listeria infection and CD8+ T cell activation.

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