2-deoxy D-glucose treatment does not elicit a hair growth response in alopecia areata.

Authors

John P Sundberg, The Jackson LaboratoryFollow
Kathleen A Silva, The Jackson LaboratoryFollow
Victoria E. Kennedy, The Jackson LaboratoryFollow
John J Wilson, The Jackson LaboratoryFollow
Nicholas E Gott, The Jackson LaboratoryFollow
Beth A. Sundberg, The Jackson LaboratoryFollow
Derry C. Roopenian, The Jackson LaboratoryFollow

Document Type

Article

Publication Date

9-2019

Keywords

JMG

JAX Source

Exp Dermatol 2019 Sep; 28(9):1091-1093

Volume

28

Issue

9

First Page

1091

Last Page

1093

ISSN

1600-0625

PMID

31323149

DOI

https://doi.org/10.1111/exd.14008

Grant

CA034196,AR049288

Abstract

2-deoxy D-glucose (2DG) was tested for efficacy in treating alopecia areata using the C3H/HeJ skin graft model. 2DG has proven to be efficacious in treatment of various mouse models of autoimmunity with minimal serious side effects noted. This agent has been shown to normalize abnormally activated T-cell populations while also preventing cell surface expression of NKG2D; key factors defining alopecia areata disease progression. Daily oral ingestion of 2DG via drinking water to mice with patchy or diffuse alopecia areata for 16 weeks failed to prevent expansion of alopecia or cause regrowth of hair in treated mice. Histologically, there were no differences between treated and control groups. These results indicate that, while 2DG is effective for some autoimmune diseases, it was not efficacious for the cell-mediated autoimmune mouse disease, alopecia areata.

Comments

The authors thank Zoe Reifsnyder for assistance with the figures.

Recommended Citation

Sundberg J, Silva K, Kennedy VE, Wilson J, Gott N, Sundberg BA, Roopenian DC. 2-deoxy D-glucose treatment does not elicit a hair growth response in alopecia areata. Exp Dermatol 2019 Sep; 28(9):1091-1093