Document Type

Article

Publication Date

11-20-2019

Keywords

JMG

JAX Source

Neuron 2019 Nov 20; 104(4):637-653

Volume

104

Issue

4

First Page

637

Last Page

653

ISSN

1097-4199

PMID

31751545

DOI

https://doi.org/10.1016/j.neuron.2019.09.018

Grant

DA039841

Abstract

Neuropathic pain (NeuP) arises due to injury of the somatosensory nervous system and is both common and disabling, rendering an urgent need for non-addictive, effective new therapies. Given the high evolutionary conservation of pain, investigative approaches from Drosophila mutagenesis to human Mendelian genetics have aided our understanding of the maladaptive plasticity underlying NeuP. Successes include the identification of ion channel variants causing hyper-excitability and the importance of neuro-immune signaling. Recent developments encompass improved sensory phenotyping in animal models and patients, brain imaging, and electrophysiology-based pain biomarkers, the collection of large well-phenotyped population cohorts, neurons derived from patient stem cells, and high-precision CRISPR generated genetic editing. We will discuss how to harness these resources to understand the pathophysiological drivers of NeuP, define its relationship with comorbidities such as anxiety, depression, and sleep disorders, and explore how to apply these findings to the prediction, diagnosis, and treatment of NeuP in the clinic.

Comments

This open access article is licensed under a Creative Commons Attribution 4.0 International License.

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