Document Type
Article
Publication Date
3-4-2019
Keywords
JMG
JAX Source
NPJ Regen Med 2019 Mar 4; 4:5
Volume
4
First Page
5
Last Page
5
ISSN
2057-3995
PMID
30854227
DOI
https://doi.org/10.1038/s41536-019-0067-6
Grant
Australia Fellowship 546133, Stem Cells Australia SR1100102
Abstract
Clinical variation in patient responses to myocardial infarction (MI) has been difficult to model in laboratory animals. To assess the genetic basis of variation in outcomes after heart attack, we characterized responses to acute MI in the Collaborative Cross (CC), a multi-parental panel of genetically diverse mouse strains. Striking differences in post-MI functional, morphological, and myocardial scar features were detected across 32 CC founder and recombinant inbred strains. Transcriptomic analyses revealed a plausible link between increased intrinsic cardiac oxidative phosphorylation levels and MI-induced heart failure. The emergence of significant quantitative trait loci for several post-MI traits indicates that utilizing CC strains is a valid approach for gene network discovery in cardiovascular disease, enabling more accurate clinical risk assessment and prediction.
Recommended Citation
Salimova E,
Nowak K,
Estrada A,
Furtado M,
McNamara E,
Nguyen Q,
Balmer L,
Preuss C,
Holmes J,
Ramialison M,
Morahan G,
Rosenthal N.
Variable outcomes of human heart attack recapitulated in genetically diverse mice. NPJ Regen Med 2019 Mar 4; 4:5
Comments
This open access article is licensed under a Creative Commons Attribution 4.0 International License