A CD4+ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate.
Document Type
Article
Publication Date
1-1-2019
Keywords
JGM
JAX Source
Nat Med 2019 Jan; 25(1):75-81
Volume
25
Issue
1
First Page
75
Last Page
81
ISSN
1546-170X
PMID
30478422
DOI
https://doi.org/10.1038/s41591-018-0254-9
Grant
AR054083,AI082715
Abstract
Understanding the mechanisms underlying autoantibody development will accelerate therapeutic target identification in autoimmune diseases such as systemic lupus erythematosus (SLE)1. Follicular helper T cells (TFH cells) have long been implicated in SLE pathogenesis. Yet a fraction of autoantibodies in individuals with SLE are unmutated, supporting that autoreactive B cells also differentiate outside germinal centers2. Here, we describe a CXCR5-CXCR3+ programmed death 1 (PD1)hiCD4+ helper T cell population distinct from TFH cells and expanded in both SLE blood and the tubulointerstitial areas of individuals with proliferative lupus nephritis. These cells produce interleukin-10 (IL-10) and accumulate mitochondrial reactive oxygen species as the result of reverse electron transport fueled by succinate. Furthermore, they provide B cell help, independently of IL-21, through IL-10 and succinate. Similar cells are generated in vitro upon priming naive CD4+ T cells with plasmacytoid dendritic cells activated with oxidized mitochondrial DNA, a distinct class of interferogenic toll-like receptor 9 ligand3. Targeting this pathway might blunt the initiation and/or perpetuation of extrafollicular humoral responses in SLE.
Recommended Citation
Caielli S,
Veiga D,
Balasubramanian P,
Athale S,
Domic B,
Murat E,
Banchereau R,
Xu Z,
Chandra M,
Chung C,
Walters L,
Baisch J,
Wright T,
Punaro M,
Nassi L,
Stewart K,
Fuller J,
Ucar D,
Ueno H,
Zhou J,
Banchereau J,
Pascual V.
A CD4+ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate. Nat Med 2019 Jan; 25(1):75-81