Extrachromosomal oncogene amplification in tumour pathogenesis and evolution.
Document Type
Article
Publication Date
5-2019
Keywords
JGM
JAX Source
Nat Rev Cancer 2019 May; 19(5):283-288
Volume
19
Issue
5
First Page
283
Last Page
288
ISSN
1474-1768
PMID
30872802
DOI
https://doi.org/10.1038/s41568-019-0128-6
Grant
CA190121,CA034196,Musella Foundation, B*CURED Foundation
Abstract
Recent reports have demonstrated that oncogene amplification on extrachromosomal DNA (ecDNA) is a frequent event in cancer, providing new momentum to explore a phenomenon first discovered several decades ago. The direct consequence of ecDNA gains in these cases is an increase in DNA copy number of the oncogenes residing on the extrachromosomal element. A secondary effect, perhaps even more important, is that the unequal segregation of ecDNA from a parental tumour cell to offspring cells rapidly increases tumour heterogeneity, thus providing the tumour with an additional array of responses to microenvironment-induced and therapy-induced stress factors and perhaps providing an evolutionary advantage. This Perspectives article discusses the current knowledge and potential implications of oncogene amplification on ecDNA in cancer.
Recommended Citation
Verhaak R,
Bafna V,
Mischel P.
Extrachromosomal oncogene amplification in tumour pathogenesis and evolution. Nat Rev Cancer 2019 May; 19(5):283-288
Comments
The authors thank C. Beck (Jackson Laboratory for Genomic Medicine), S. Wu and K. M. Turner (Mischel laboratory) for feedback on the manuscript content and S. Cassidy (Jackson Laboratory for Genomic Medicine) for support in manuscript writing.