Document Type
Article
Publication Date
6-15-2020
Keywords
JMG
JAX Source
PLoS One 2020 Jun 15; 15(6):e0230162
Volume
15
Issue
6
First Page
0230162
Last Page
0230162
ISSN
1932-6203
PMID
32542000
DOI
https://doi.org/10.1371/journal.pone.0230162
Abstract
Dislocation in hindlimb tarsals are being observed at a low, but persistent frequency in group-housed adult male mice from C57BL/6N substrains. Clinical signs included a sudden onset of mild to severe unilateral or bilateral tarsal abduction, swelling, abnormal hindlimb morphology and lameness. Contraction of digits and gait abnormalities were noted in multiple cases. Radiographical and histological examination revealed caudal dislocation of the calcaneus and partial dislocation of the calcaneoquartal (calcaneus-tarsal bone IV) joint. The detection, frequency, and cause of this pathology in five large mouse production and phenotyping centres (MRC Harwell, UK; The Jackson Laboratory, USA; The Centre for Phenogenomics, Canada; German Mouse Clinic, Germany; Baylor College of Medicine, USA) are discussed.
Recommended Citation
Herbert E,
Stewart M,
Hutchison M,
Flenniken A,
Qu D,
Nutter L,
McKerlie C,
Hobson L,
Kick B,
Lyons BL,
Wiegand J,
Doty RA,
Aguilar-Pimentel J,
Hrabe de Angelis M,
Dickinson M,
Seavitt J,
White J,
Scudamore C,
Wells S.
The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities. PLoS One 2020 Jun 15; 15(6):e0230162
Comments
We thank staff at the five facilities participating in this study for animal husbandry support, necropsy, and histology services. Dr Dona Reddiar for assistance with the manuscript.
This is an open access article distributed under the terms of the Creative Commons Attribution license.