Document Type

Article

Publication Date

6-15-2020

Keywords

JMG

JAX Source

PLoS One 2020 Jun 15; 15(6):e0230162

PMID

32542000

DOI

https://doi.org/10.1371/journal.pone.0230162

Abstract

Dislocation in hindlimb tarsals are being observed at a low, but persistent frequency in group-housed adult male mice from C57BL/6N substrains. Clinical signs included a sudden onset of mild to severe unilateral or bilateral tarsal abduction, swelling, abnormal hindlimb morphology and lameness. Contraction of digits and gait abnormalities were noted in multiple cases. Radiographical and histological examination revealed caudal dislocation of the calcaneus and partial dislocation of the calcaneoquartal (calcaneus-tarsal bone IV) joint. The detection, frequency, and cause of this pathology in five large mouse production and phenotyping centres (MRC Harwell, UK; The Jackson Laboratory, USA; The Centre for Phenogenomics, Canada; German Mouse Clinic, Germany; Baylor College of Medicine, USA) are discussed.

Comments

We thank staff at the five facilities participating in this study for animal husbandry support, necropsy, and histology services. Dr Dona Reddiar for assistance with the manuscript.

This is an open access article distributed under the terms of the Creative Commons Attribution license.

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