Document Type
Article
Publication Date
1-1-2020
JAX Location
Sarcoma 2020 May 4; 2020:6312480
Volume
2020
First Page
6312480
Last Page
6312480
ISSN
1357-714X
PMID
32565715
DOI
https://doi.org/10.1155/2020/6312480
Abstract
Nonrhabdomyosarcoma soft-tissue sarcomas (STSs) are a class of 50+ cancers arising in muscle and soft tissues of children, adolescents, and adults. Rarity of each subtype often precludes subtype-specific preclinical research, leaving many STS patients with limited treatment options should frontline therapy be insufficient. When clinical options are exhausted, personalized therapy assignment approaches may help direct patient care. Here, we report the results of an adult female STS patient with relapsed undifferentiated pleomorphic sarcoma (UPS) who self-drove exploration of a wide array of personalized Clinical Laboratory Improvement Amendments (CLIAs) level and research-level diagnostics, including state of the art genomic, proteomic,
Recommended Citation
Berlow N,
Grasso C,
Quist M,
Cheng M,
Gandour-Edwards R,
Hernandez B,
Michalek J,
Ryan C,
Spellman P,
Pal R,
Million L,
Renneker M,
Keller C.
Deep Functional and Molecular Characterization of a High-Risk Undifferentiated Pleomorphic Sarcoma. . 2020; 2020():6312480
Comments
0e authors thank Dr. Susie Airhart, Dr. Carol Bult, and Dr. Jim Keck of the Jackson Laboratory for their assistance and support in the patient-derived xenograft studies of PCB-209. 0e authors thank the patient for sharing clinical- and research- level data to understand UPS.
Open access under the terms of the Creative Commons Attribution License.