Deep Functional and Molecular Characterization of a High-Risk Undifferentiated Pleomorphic Sarcoma.
Sarcoma 2020 May 4; 2020:6312480
Nonrhabdomyosarcoma soft-tissue sarcomas (STSs) are a class of 50+ cancers arising in muscle and soft tissues of children, adolescents, and adults. Rarity of each subtype often precludes subtype-specific preclinical research, leaving many STS patients with limited treatment options should frontline therapy be insufficient. When clinical options are exhausted, personalized therapy assignment approaches may help direct patient care. Here, we report the results of an adult female STS patient with relapsed undifferentiated pleomorphic sarcoma (UPS) who self-drove exploration of a wide array of personalized Clinical Laboratory Improvement Amendments (CLIAs) level and research-level diagnostics, including state of the art genomic, proteomic,
Berlow, Noah E; Grasso, Catherine S; Quist, Michael J; Cheng, Mingshan; Gandour-Edwards, Regina; Hernandez, Brian S; Michalek, Joel E; Ryan, Christopher; Spellman, Paul; Pal, Ranadip; Million, Lynn S; Renneker, Mark; and Keller, Charles, "Deep Functional and Molecular Characterization of a High-Risk Undifferentiated Pleomorphic Sarcoma." (2020). Faculty Research 2020. 113.
0e authors thank Dr. Susie Airhart, Dr. Carol Bult, and Dr. Jim Keck of the Jackson Laboratory for their assistance and support in the patient-derived xenograft studies of PCB-209. 0e authors thank the patient for sharing clinical- and research- level data to understand UPS.
Open access under the terms of the Creative Commons Attribution License.