STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells.
Document Type
Article
Publication Date
7-1-2020
Keywords
JGM, JAXCC
JAX Source
EMBO Mol Med 2020 Jul 1; e11592
First Page
11592
Last Page
11592
ISSN
1757-4684
PMID
32609955
DOI
https://doi.org/10.15252/emmm.201911592
Grant
AI065303
Abstract
Immunity to fungal infections is mediated by cells of the innate and adaptive immune system including Th17 cells. Ca2+ influx in immune cells is regulated by stromal interaction molecule 1 (STIM1) and its activation of the Ca2+ channel ORAI1. We here identify patients with a novel mutation in STIM1 (p.L374P) that abolished Ca2+ influx and resulted in increased susceptibility to fungal and other infections. In mice, deletion of STIM1 in all immune cells enhanced susceptibility to mucosal C. albicans infection, whereas T cell-specific deletion of STIM1 impaired immunity to systemic C. albicans infection. STIM1 deletion impaired the production of Th17 cytokines essential for antifungal immunity and compromised the expression of genes in several metabolic pathways including Foxo and HIF1α signaling that regulate glycolysis and oxidative phosphorylation (OXPHOS). Our study further revealed distinct roles of STIM1 in regulating transcription and metabolic programs in non-pathogenic Th17 cells compared to pathogenic, proinflammatory Th17 cells, a finding that may potentially be exploited for the treatment of Th17 cell-mediated inflammatory diseases.
Recommended Citation
Kahlfuss S,
Kaufmann U,
Concepcion A,
Noyer L,
Raphael D,
Vaeth M,
Yang J,
Pancholi P,
Maus M,
Muller J,
Kozhaya L,
Khodadadi-Jamayran A,
Sun Z,
Shaw P,
Unutmaz D,
Stathopulos P,
Feist C,
Cameron S,
Turvey S,
Feske S.
STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells. EMBO Mol Med 2020 Jul 1; e11592