Understanding Normal and Malignant Human Hematopoiesis Using Next-Generation Humanized Mice.

Document Type

Article

Publication Date

8-2020

Keywords

JMG, JAXCC

JAX Source

Trends Immune 2020 Aug; 41(8):706-20

Volume

41

Issue

8

First Page

706

Last Page

720

ISSN

1471-4981

PMID

32631635

DOI

https://doi.org/10.1016/j.it.2020.06.004

Abstract

Rodent models for human diseases contribute significantly to understanding human physiology and pathophysiology. However, given the accelerating pace of drug development, there is a crucial need for in vivo preclinical models of human biology and pathology. The humanized mouse is one tool to bridge the gap between traditional animal models and the clinic. The development of immunodeficient mouse strains with high-level engraftment of normal and diseased human immune/hematopoietic cells has made in vivo functional characterization possible. As a patient-derived xenograft (PDX) model, humanized mice functionally correlate putative mechanisms with in vivo behavior and help to reveal pathogenic mechanisms. Combined with single-cell genomics, humanized mice can facilitate functional precision medicine such as risk stratification and individually optimized therapeutic approaches.

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