Document Type
Article
Publication Date
8-26-2020
Keywords
JGM, JAXCC
JAX Source
Genome Biol 2020 Aug 26; 21(1):216
Volume
21
Issue
1
First Page
216
Last Page
216
ISSN
1474-760X
PMID
32847614
DOI
https://doi.org/10.1186/s13059-020-02140-x
Abstract
BACKGROUND: Glioblastoma (GBM) is a complex disease with extensive molecular and transcriptional heterogeneity. GBM can be subcategorized into four distinct subtypes; tumors that shift towards the mesenchymal phenotype upon recurrence are generally associated with treatment resistance, unfavorable prognosis, and the infiltration of pro-tumorigenic macrophages.
RESULTS: We explore the transcriptional regulatory networks of mesenchymal-associated tumor-associated macrophages (MA-TAMs), which drive the malignant phenotypic state of GBM, and identify macrophage receptor with collagenous structure (MARCO) as the most highly differentially expressed gene. MARCO
CONCLUSIONS: Collectively, our study characterizes the global transcriptional profile of TAMs driving mesenchymal GBM pathogenesis, providing potential therapeutic targets for improving the effectiveness of GBM immunotherapy.
Recommended Citation
Sa J,
Chang N,
Lee H,
Cho H,
Ceccarelli M,
Cerulo L,
Yin J,
Kim S,
Caruso F,
Lee M,
Kim D,
Oh Y,
Lee Y,
Her N,
Min B,
Kim H,
Jeong D,
Kim H,
Kim H,
Chung S,
Woo H,
Lee J,
Kong D,
Seol H,
Lee J,
Kim J,
Park W,
Wang Q,
Sulman E,
Heimberger A,
Lim M,
Park J,
Iavarone A,
Verhaak R,
Nam D.
Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma. Genome Biol 2020 Aug 26; 21(1):216
Comments
This article is distributed under the terms of the Creative Commons Attribution- NonCommercial 4.0 License