Genome Biol 2020 Aug 26; 21(1):216
BACKGROUND: Glioblastoma (GBM) is a complex disease with extensive molecular and transcriptional heterogeneity. GBM can be subcategorized into four distinct subtypes; tumors that shift towards the mesenchymal phenotype upon recurrence are generally associated with treatment resistance, unfavorable prognosis, and the infiltration of pro-tumorigenic macrophages.
RESULTS: We explore the transcriptional regulatory networks of mesenchymal-associated tumor-associated macrophages (MA-TAMs), which drive the malignant phenotypic state of GBM, and identify macrophage receptor with collagenous structure (MARCO) as the most highly differentially expressed gene. MARCO
CONCLUSIONS: Collectively, our study characterizes the global transcriptional profile of TAMs driving mesenchymal GBM pathogenesis, providing potential therapeutic targets for improving the effectiveness of GBM immunotherapy.
Sa, Jason K; Chang, Nakho; Lee, Hye Won; Cho, Hee Jin; Ceccarelli, Michele; Cerulo, Luigi; Yin, Jinlong; Kim, Sung Soo; Caruso, Francesca P; Lee, Mijeong; Kim, Donggeon; Oh, Young Taek; Lee, Yeri; Her, Nam-Gu; Min, Byeongkwi; Kim, Hye-Jin; Jeong, Da Eun; Kim, Hye-Mi; Kim, Hyunho; Chung, Seok; Woo, Hyun Goo; Lee, Jeongwu; Kong, Doo-Sik; Seol, Ho Jun; Lee, Jung-Il; Kim, Jinho; Park, Woong-Yang; Wang, Qianghu; Sulman, Erik P; Heimberger, Amy B; Lim, Michael; Park, Jong Bae; Iavarone, Antonio; Verhaak, Roel G W; and Nam, Do-Hyun, "Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma." (2020). Faculty Research 2020. 179.