Document Type

Article

Publication Date

8-26-2020

Keywords

JGM, JAXCC

JAX Source

Genome Biol 2020 Aug 26; 21(1):216

PMID

32847614

DOI

https://doi.org/10.1186/s13059-020-02140-x

Abstract

BACKGROUND: Glioblastoma (GBM) is a complex disease with extensive molecular and transcriptional heterogeneity. GBM can be subcategorized into four distinct subtypes; tumors that shift towards the mesenchymal phenotype upon recurrence are generally associated with treatment resistance, unfavorable prognosis, and the infiltration of pro-tumorigenic macrophages.

RESULTS: We explore the transcriptional regulatory networks of mesenchymal-associated tumor-associated macrophages (MA-TAMs), which drive the malignant phenotypic state of GBM, and identify macrophage receptor with collagenous structure (MARCO) as the most highly differentially expressed gene. MARCO

CONCLUSIONS: Collectively, our study characterizes the global transcriptional profile of TAMs driving mesenchymal GBM pathogenesis, providing potential therapeutic targets for improving the effectiveness of GBM immunotherapy.

Comments

This article is distributed under the terms of the Creative Commons Attribution- NonCommercial 4.0 License

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