Molecular Biology and Evolution of Cancer: From Discovery to Action.
Document Type
Article
Publication Date
2-1-2020
Keywords
JGM, JAXCC
JAX Source
Mol Biol Evol 2020 Feb; 37(2):320-326
Volume
37
Issue
2
First Page
320
Last Page
326
ISSN
1537-1719
PMID
31642480
DOI
https://doi.org/10.1093/molbev/msz242
Abstract
Cancer progression is an evolutionary process. During this process, evolving cancer cell populations encounter restrictive ecological niches within the body, such as the primary tumor, circulatory system, and diverse metastatic sites. Efforts to prevent or delay cancer evolution-and progression-require a deep understanding of the underlying molecular evolutionary processes. Herein we discuss a suite of concepts and tools from evolutionary and ecological theory that can inform cancer biology in new and meaningful ways. We also highlight current challenges to applying these concepts, and propose ways in which incorporating these concepts could identify new therapeutic modes and vulnerabilities in cancer.
Recommended Citation
Somarelli J,
Gardner H,
Cannataro V,
Gunady E,
Boddy A,
Johnson N,
Fisk J,
Gaffney S,
Chuang J,
Li S,
Ciccarelli F,
Panchenko A,
Megquier K,
Kumar S,
Dornburg A,
DeGregori J,
Townsend J.
Molecular Biology and Evolution of Cancer: From Discovery to Action. Mol Biol Evol 2020 Feb; 37(2):320-326