Development of a Cardiac Sarcomere Functional Genomics Platform to Enable Scalable Interrogation of Human

Authors

Anthony M Pettinato, The Jackson LaboratoryFollow
Feria A Ladha, The Jackson LaboratoryFollow
David J Mellert, The Jackson LaboratoryFollow
Nicholas Legere
Rachel Cohn, The Jackson LaboratoryFollow
Robert Romano, The Jackson LaboratoryFollow
Ketan Thakar, The Jackson LaboratoryFollow
Yu-Sheng Chen
J Travis Hinson, The Jackson LaboratoryFollow

Document Type

Article

Publication Date

12-8-2020

Keywords

JGM

JAX Source

Circulation 2020 Dec 8; 142(23):2262-2275

Volume

142

Issue

23

First Page

2262

Last Page

2275

ISSN

1524-4539

PMID

33025817

DOI

https://doi.org/10.1161/circulationaha.120.047999

Grant

HL125807; HL142787; EB028898; PRE343181021; PRE35110005

Abstract

BACKGROUND: Pathogenic

METHODS: We created a toolkit of human induced pluripotent stem cell models and functional assays using CRISPR/Cas9 to study

RESULTS: Hypertrophic cardiomyopathy-associated

CONCLUSIONS: Our study found that hypertrophic cardiomyopathy-associated

Comments

The authors thank A. Carcio and T. Prosio (The Jackson Laboratory for Genomic Medicine) for expertise in flow cytometry.

Recommended Citation

Pettinato A, Ladha F, Mellert D, Legere N, Cohn R, Romano R, Thakar K, Chen Y, Hinson J. Development of a Cardiac Sarcomere Functional Genomics Platform to Enable Scalable Interrogation of Human Circulation 2020 Dec 8; 142(23):2262-2275