Longitudinal Analysis of Serum Cytokine Levels and Gut Microbial Abundance Links IL-17/IL-22 With
Document Type
Article
Publication Date
8-2020
Keywords
JGM; Bayes Theorem, Firmicutes, Gastrointestinal Microbiome, Humans, Interleukin-17, Interleukins, Longitudinal Studies, Microbiota, Prediabetic State
JAX Source
Diabetes 2020 Aug; 69(8):1833-1842
Volume
69
Issue
8
First Page
1833
Last Page
1842
ISSN
1939-327X
PMID
32366680
DOI
https://doi.org/10.2337/db19-0592
Grant
DE02378901
Abstract
Recent studies using mouse models suggest that interaction between the gut microbiome and IL-17/IL-22-producing cells plays a role in the development of metabolic diseases. We investigated this relationship in humans using data from the prediabetes study of the Integrated Human Microbiome Project (iHMP). Specifically, we addressed the hypothesis that early in the onset of metabolic diseases there is a decline in serum levels of IL-17/IL-22, with concomitant changes in the gut microbiome. Clustering iHMP study participants on the basis of longitudinal IL-17/IL-22 profiles identified discrete groups. Individuals distinguished by low levels of IL-17/IL-22 were linked to established markers of metabolic disease, including insulin sensitivity. These individuals also displayed gut microbiome dysbiosis, characterized by decreased diversity, and IL-17/IL-22-related declines in the phylum
Recommended Citation
Zhou X,
Johnson J,
Spakowicz D,
Zhou W,
Zhou Y,
Sodergren E,
Snyder M,
Weinstock GM.
Longitudinal Analysis of Serum Cytokine Levels and Gut Microbial Abundance Links IL-17/IL-22 With Diabetes 2020 Aug; 69(8):1833-1842