Title

Longitudinal Analysis of Serum Cytokine Levels and Gut Microbial Abundance Links IL-17/IL-22 With

Document Type

Article

Publication Date

8-2020

Keywords

JGM; Bayes Theorem, Firmicutes, Gastrointestinal Microbiome, Humans, Interleukin-17, Interleukins, Longitudinal Studies, Microbiota, Prediabetic State

JAX Source

Diabetes 2020 Aug; 69(8):1833-1842

PMID

32366680

DOI

https://doi.org/10.2337/db19-0592

Grant

DE02378901

Abstract

Recent studies using mouse models suggest that interaction between the gut microbiome and IL-17/IL-22-producing cells plays a role in the development of metabolic diseases. We investigated this relationship in humans using data from the prediabetes study of the Integrated Human Microbiome Project (iHMP). Specifically, we addressed the hypothesis that early in the onset of metabolic diseases there is a decline in serum levels of IL-17/IL-22, with concomitant changes in the gut microbiome. Clustering iHMP study participants on the basis of longitudinal IL-17/IL-22 profiles identified discrete groups. Individuals distinguished by low levels of IL-17/IL-22 were linked to established markers of metabolic disease, including insulin sensitivity. These individuals also displayed gut microbiome dysbiosis, characterized by decreased diversity, and IL-17/IL-22-related declines in the phylum

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