Long noncoding RNA SMUL suppresses SMURF2 production-mediated muscle atrophy via nonsense-mediated mRNA decay.
Document Type
Article
Publication Date
12-10-2020
Keywords
JMG
JAX Source
Mol There Nucleic Acids 2020 Dec 10; 23:512-526.
Volume
23
First Page
512
Last Page
526
ISSN
2162-2531
PMID
33510940
DOI
https://doi.org/10.1016/j.omtn.2020.12.003
Abstract
As the world population grows, muscle atrophy leading to muscle wasting could become a bigger risk. Long noncoding RNAs (lncRNAs) are known to play important roles in muscle growth and muscle atrophy. Meanwhile, it has recently come to light that many putative small open reading frames (sORFs) are hidden in lncRNAs; however, their translational capabilities and functions remain unclear. In this study, we uncovered 104 myogenic-associated lncRNAs translated, in at least a small peptide, by integrated transcriptome and proteomic analyses. Furthermore, an upstream ORF (uORF) regulatory network was constructed, and a novel muscle atrophy-associated lncRNA named
Recommended Citation
Cai B,
Li Z,
Ma M,
Zhang J,
Kong S,
Abdalla B,
Xu H,
Jebessa E,
Zhang X,
Lawal R,
Nie Q.
Long noncoding RNA SMUL suppresses SMURF2 production-mediated muscle atrophy via nonsense-mediated mRNA decay. Mol There Nucleic Acids 2020 Dec 10; 23:512-526.