Document Type
Article
Publication Date
2-3-2020
Keywords
JMG
JAX Source
Genes Brain Behav 2020 Feb 3; e12645
First Page
12645
Last Page
12645
ISSN
1601-183X
PMID
32012419
DOI
https://doi.org/10.1111/gbb.12645
Abstract
Despite substantial evidence for sex differences in addiction epidemiology, addiction-relevant behaviors and associated neurobiological phenomena, the mechanisms and implications of these differences remain unknown. Genetic analysis in model organism is a potentially powerful and effective means of discovering the mechanisms that underlie sex differences in addiction. Human genetic studies are beginning to show precise risk variants that influence the mechanisms of addiction but typically lack sufficient power or neurobiological mechanistic access, particularly for the discovery of the mechanisms that underlie sex differences. Our thesis in this review is that genetic variation in model organisms are a promising approach that can complement these investigations to show the biological mechanisms that underlie sex differences in addiction.
Recommended Citation
Datta U,
Schoenrock S,
Bubier JA,
Bogue MA,
Jentsch J,
Logan R,
Tarantino L,
Chesler E.
Prospects for finding the mechanisms of sex differences in addiction with human and model organism genetic analysis. Genes Brain Behav 2020 Feb 3; e12645
Comments
Open access under the terms of the Creative Commons Attribution License