Comparative Molecular Life History of Spontaneous Canine and Human Gliomas.
Document Type
Article
Publication Date
2-10-2020
Keywords
JGM, JMG
JAX Source
Cancer Cell 2020 Feb 10;37(2):243-257.e7
Volume
37
Issue
2
First Page
243
Last Page
257
ISSN
1878-3686
PMID
32049048
DOI
https://doi.org/10.1016/j.ccell.2020.01.004
Grant
CA16672,CA034196,CA190121,CA226387, JAX Scholar Program, American Cancer Society Fellowship
Abstract
Sporadic gliomas in companion dogs provide a window on the interaction between tumorigenic mechanisms and host environment. We compared the molecular profiles of canine gliomas with those of human pediatric and adult gliomas to characterize evolutionarily conserved mammalian mutational processes in gliomagenesis. Employing whole-genome, exome, transcriptome, and methylation sequencing of 83 canine gliomas, we found alterations shared between canine and human gliomas such as the receptor tyrosine kinases, TP53 and cell-cycle pathways, and IDH1 R132. Canine gliomas showed high similarity with human pediatric gliomas per robust aneuploidy, mutational rates, relative timing of mutations, and DNA-methylation patterns. Our cross-species comparative genomic analysis provides unique insights into glioma etiology and the chronology of glioma-causing somatic alterations.
Recommended Citation
Amin S,
Anderson K,
Boudreau C,
Martinez-Ledesma E,
Kocakavuk E,
Johnson K,
Barthel F,
Varn F,
Kassab C,
Ling X,
Kim H,
Barter M,
Lau C,
Ngan C,
Chapman M,
Koehler J,
Long J,
Miller A,
Miller C,
Porter B,
Rissi D,
Mazcko C,
LeBlanc A,
Dickinson P,
Packer R,
Taylor A,
Rossmeisl J,
Woolard K,
Heimberger A,
Levine J,
Verhaak R.
Comparative Molecular Life History of Spontaneous Canine and Human Gliomas. Cancer Cell 2020 Feb 10;37(2):243-257.e7