Document Type
Article
Publication Date
3-1-2020
Keywords
JMG, JGM, JAXCC
JAX Source
Genetics 2020 Mar; 214(3):719-733
Volume
214
Issue
3
First Page
719
Last Page
733
ISSN
1943-2631
PMID
31896565
DOI
https://doi.org/10.1534/genetics.119.303013
Grant
DA043809
Abstract
The microbiome influences health and disease through complex networks of host genetics, genomics, microbes, and environment. Identifying the mechanisms of these interactions has remained challenging. Systems genetics in laboratory mice (Mus musculus) enables data-driven discovery of biological network components and mechanisms of host-microbial interactions underlying disease phenotypes. To examine the interplay among the whole host genome, transcriptome, and microbiome, we mapped QTL and correlated the abundance of cecal messenger RNA, luminal microflora, physiology, and behavior in a highly diverse Collaborative Cross breeding population. One such relationship, regulated by a variant on chromosome 7, was the association of Odoribacter (Bacteroidales) abundance and sleep phenotypes. In a test of this association in the BKS.Cg-Dock7m +/+ Leprdb/J mouse model of obesity and diabetes, known to have abnormal sleep and colonization by Odoribacter, treatment with antibiotics altered sleep in a genotype-dependent fashion. The many other relationships extracted from this study can be used to interrogate other diseases, microbes, and mechanisms.
Recommended Citation
Bubier JA,
Philip VM,
Quince C,
Campbell J,
Zhou Y,
Vishnivetskaya T,
Duvvuru S,
Blair R,
Ndukum J,
Donohue K,
Foster C,
Mellert D,
Weinstock GM,
Culiat C,
O'Hara B,
Palumbo A,
Podar M,
Chesler E.
A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice. Genetics 2020 Mar; 214(3):719-733
Comments
Jennifer Ryan, Neil Cole, Christine Rosales, Laura Anderson and Samantha 636 Burrill conducted db sleep studies and dissections.
This open access article is licensed under a Creative Commons Attribution 4.0 International License