Document Type

Article

Publication Date

5-25-2020

Keywords

JMG

JAX Source

Mol Brain 2020 May 25; 13(1):81

Volume

13

Issue

1

First Page

81

Last Page

81

ISSN

1756-6606

PMID

32450896

DOI

https://doi.org/10.1186/s13041-020-00603-7

Abstract

Glaucoma is the leading cause of irreversible vision loss. Ocular hypertension is a major risk factor for glaucoma and recent work has demonstrated critical early neuroinflammatory insults occur in the optic nerve head following ocular hypertension. Microglia and infiltrating monocytes are likely candidates to drive these neuroinflammatory insults. However, the exact molecular identity / transcriptomic profile of microglia following ocular hypertensive insults is unknown. To elucidate the molecular identity of microglia after long-term exposure to ocular hypertension, we used a mouse model of glaucoma (DBA/2 J). We performed RNA-sequencing of microglia mRNA from the optic nerve head at a time point following ocular hypertensive insults, but preceding detectable neurodegeneration (with microglia identified as being CD45

Comments

This article is licensed under a Creative Commons Attribution 4.0 International License.

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