Document Type

Article

Publication Date

12-2021

Publication Title

Neurobiology of disease

Keywords

JMG

JAX Source

Neurobiol Dis 2021 Dec; 161:105558

Volume

161

First Page

105558

Last Page

105558

ISSN

1095-953X

PMID

34767943

DOI

https://doi.org/10.1016/j.nbd.2021.105558

Grant

AG057914

Abstract

Alzheimer's disease (AD) is a complex disease that is mediated by numerous factors and manifests in various forms. A systems biology approach to studying AD involves analyses of various body systems, biological scales, environmental elements, and clinical outcomes to understand the genotype to phenotype relationship that potentially drives AD development. Currently, there are many research investigations probing how modifiable and nonmodifiable factors impact AD symptom presentation. This review specifically focuses on how imaging modalities can be integrated into systems biology approaches using model mouse populations to link brain level functional and structural changes to disease onset and progression. Combining imaging and omics data promotes the classification of AD into subtypes and paves the way for precision medicine solutions to prevent and treat AD.

Comments

The authors would also like to thank Dr. Kristen O’Connell, Dr. Niran Hadad, Dr. Amy Dunn, Dr. Maria Telpoukhovskaia, and Dr. Jillian King for their thoughtful review and editing.

This is an open access article under the CC BY-NC-ND license.

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