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Submissions from 2021

Microbial signatures of health, gingivitis, and periodontitis., Loreto Abusleme, Anilei Hoare, Bo-Young Hong, and Patricia I Diaz

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A Computational Systems Analyses to Identify Biomarkers and Mechanistic Link in Psoriasis and Cutaneous Squamous Cell Carcinoma., Sidra Adil, Rehan Zafar Paracha, Salma Tariq, Maryum Nisar, Sadaf Ijaz, Amnah Siddiqa, Zamir Hussain, and Afreenish Amir

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A functional variant on 20q13.33 related to glioma risk alters enhancer activity and modulates expression of multiple genes., Mourad Wagdy Ali, C Pawan K Patro, Jacqueline Jufen Zhu, Christopher H Dampier, Sarah J Plummer, Cem Kuscu, Mazhar Adli, Ching C Lau, Rose K Lai, and Graham Casey

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The Accreditation Council for Genetic Counseling's response to COVID-19 impact on genetic counseling programs., Dawn C Allain, Susan Randall Armel, Erin P Carmany, Heather Creswick, Sarah B McBrien, E Kate Reed, and Janet L Williams

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Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data., Matthew C Altman, Darawan Rinchai, Nicole Baldwin, Mohammed Toufiq, Elizabeth Whalen, Mathieu Garand, Basirudeen Syed Ahamed Kabeer, Mohamed Alfaki, Scott R Presnell, Prasong Khaenam, Aaron Ayllón-Benítez, Fleur Mougin, Patricia Thébault, Laurent Chiche, Noemie Jourde-Chiche, J Theodore Phillips, Goran Klintmalm, Anne O'Garra, Matthew Berry, Chloe Bloom, Robert J Wilkinson, Christine M Graham, Marc Lipman, Ganjana Lertmemongkolchai, Davide Bedognetti, Rodolphe Thiebaut, Farrah Kheradmand, Asuncion Mejias, Octavio Ramilo, Karolina Palucka, Virginia Pascual, Jacques Banchereau, and Damien Chaussabel

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Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response., Ruhul Amin, Anjali Shukla, Jacqueline Jufen Zhu, Sohyoung Kim, Ping Wang, Simon Zhongyuan Tian, Andy D Tran, Debasish Paul, Steven D Cappell, Sandra Burkett, Huaitian Liu, Maxwell P Lee, Michael J Kruhlak, Jennifer E Dwyer, R Mark Simpson, Gordon L Hager, Yijun Ruan, and Kent W Hunter

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Patients' Expectations of Benefits From Large-Panel Genomic Tumor Testing in Rural Community Oncology Practices., Eric C Anderson, John DiPalazzo, Emily A Edelman, Petra Helbig, Kate Reed, Susan Miesfeldt, Christian Thomas, F Lee Lucas, Anny T H R Fenton, Andrey Antov, Michael J Hall, J Scott Roberts, Jens Rueter, and Paul K J Han

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Community oncologists' perceptions and utilization of large-panel genomic tumor testing., Eric C Anderson, Alexandra C Hinton, Christine W Lary, Anny T H R Fenton, Andrey Antov, Emily A Edelman, Petra Helbig, Kate Reed, Susan Miesfeldt, Christian A Thomas, Michael J Hall, J Scott Roberts, Jens Rueter, Paul K J Han, and MCGI Working Group

The influence of uncertainty and uncertainty tolerance on attitudes and self-efficacy about genomic tumor testing., Eric C Anderson, Alexandra Hinton, Christine W Lary, Tania Strout, Andrey Antov, Emily A Edelman, Petra Helbig, Kate Reed, Jens Rueter, and Paul K J Han

Splicing alterations in healthy aging and disease., Brittany Lynn Angarola and Olga Anczuków

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Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell death., Rosalind L Ang, Mark Chan, Diana Legarda, John P Sundberg, Shao-Cong Sun, Virginia L Gillespie, Nicholas Chun, Peter S Heeger, Huabao Xiong, Sergio A Lira, and Adrian T Ting

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Relating multivariate shapes to genescapes using phenotype-biological process associations for craniofacial shape., Jose D Aponte, David C Katz, Daniela M Roth, Marta Vidal-García, Wei Liu, Fernando Andrade, Charles C Roseman, Stephen A Murray, James Cheverud, Daniel Graf, Ralph S Marcucio, and Benedikt Hallgrímsson

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A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus., Boaz E Aronson, Laurianne Scourzic, Veevek Shah, Emily Swanzey, Andreas Kloetgen, Alexander Polyzos, Abhishek Sinha, Annabel Azziz, Inbal Caspi, Jiexi Li, Bobbie Pelham-Webb, Rachel A Glenn, Thomas Vierbuchen, Hynek Wichterle, Aristotelis Tsirigos, Meelad M Dawlaty, Matthias Stadtfeld, and Effie Apostolou

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Population and subspecies diversity at mouse centromere satellites., Uma P Arora, Caleigh Charlebois, Raman Akinyanju Lawal, and Beth L Dumont

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A Platform for Experimental Precision Medicine: The Extended BXD Mouse Family., David G Ashbrook, Danny Arends, Pjotr Prins, Megan K Mulligan, Suheeta Roy, Evan G Williams, Cathleen Lutz, Alicia Valenzuela, Casey J Bohl, Jesse F Ingels, Melinda S McCarty, Arthur G Centeno, Reinmar Hager, Johan Auwerx, Lu Lu, and Robert W Williams

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Regen med therapeutic opportunities for fighting COVID-19., Anthony Atala, Alicia Henn, Martha Lundberg, Taby Ahsan, Jordan Greenberg, Jeff Krukin, Steven Lynum, Cathleen Lutz, Kyle Cetrulo, Mohammad Albanna, Taciana Pereira, Shannon Eaker, and Joshua Hunsberger

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Differential RNA methylation using multivariate statistical methods., Deepak Nag Ayyala, Jianan Lin, and Zhengqing Ouyang

Heritability of ethanol consumption and pharmacokinetics in a genetically diverse panel of collaborative cross mouse strains and their inbred founders., Jared R Bagley, Elissa J Chesler, Vivek M. Philip, Center for Systems Genetics of Addiction, and James D Jentsch

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SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis., Adam L Bailey, Oleksandr Dmytrenko, Lina Greenberg, Andrea L Bredemeyer, Pan Ma, Jing Liu, Vinay Penna, Emma S Winkler, Sanja Sviben, Erin Brooks, Ajith P Nair, Kent A Heck, Aniket S Rali, Leo Simpson, Mehrdad Saririan, Dan Hobohm, W Tom Stump, James A Fitzpatrick, Xuping Xie, Xianwen Zhang, Pei-Yong Shi, J Travis Hinson, Weng-Tein Gi, Constanze Schmidt, Florian Leuschner, Chieh-Yu Lin, Michael S Diamond, Michael J Greenberg, and Kory J Lavine

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Heritable variation in locomotion, reward sensitivity and impulsive behaviors in a genetically diverse inbred mouse panel., Lauren S Bailey, Jared R Bagley, Rainy Dodd, Ashley A Olson, Mikayla Bolduc, Vivek M. Philip, Laura G Reinholdt, Stacey J Sukoff Rizzo, Lisa Tarantino, Leona H. Gagnon, Elissa J Chesler, and James David Jentsch

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The mouse Gene Expression Database (GXD): 2021 update., Richard M. Baldarelli, Constance M. Smith, Jacqueline H. Finger, Terry F. Hayamizu, Ingeborg J. McCright, Jingxia Xu, David R. Shaw, Jonathan S Beal, Olin Blodgett, Jeff Campbell, Lori E. Corbani, Pete J. Frost, Sharon C Giannatto, Dave Miers, James A. Kadin, Joel E Richardson, and Martin Ringwald

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Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine., Yasaman Barekatain, Jeffrey J Ackroyd, Victoria C Yan, Sunada Khadka, Lin Wang, Ko-Chien Chen, Anton H Poral, Theresa Tran, Dimitra K Georgiou, Kenisha Arthur, Yu-Hsi Lin, Nikunj Satani, Elliot S Ballato, Eliot I Behr, Ana C deCarvalho, Roel G W Verhaak, John de Groot, Jason T Huse, John M Asara, Raghu Kalluri, and Florian L Muller

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Corneal nonmyelinating Schwann cells illuminated by single-cell transcriptomics and visualized by protein biomarkers., Paola Bargagna-Mohan, Gwendolyn Schultz, Bruce Rheaume, Ephraim F Trakhtenberg, Paul Robson, Sonali Pal-Ghosh, Mary Ann Stepp, Katherine S Given, Wendy B Macklin, and Royce Mohan

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Sylvatic Canine Morbillivirus in Captive Panthera Highlights Viral Promiscuity and the Need for Better Prevention Strategies, Mainity Batista Linhares, Herbert E Whiteley, Jonathan P Samuelson, Shih Hsuan Hsiao, Adam W Stern, Ian T Sprandel, Patrick J Roady, David Coleman, Rebecca Rizzo, S Fred Froderman, and Karen A Terio

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A nomenclature for echinoderm genes., Thomas R Beatman, Katherine M Buckley, Gregory A. Cary, Veronica F Hinman, and Charles A Ettensohn

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Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery., Bahar Behsaz, Edna Bode, Alexey Gurevich, Yan-Ni Shi, Florian Grundmann, Deepa Acharya, Andrés Mauricio Caraballo-Rodríguez, Amina Bouslimani, Morgan Panitchpakdi, Annabell Linck, Changhui Guan, Julia Oh, Pieter C Dorrestein, Helge B Bode, Pavel A Pevzner, and Hosein Mohimani

Know Your Model: A brief history of making mutant mouse genetic models., Susan M. Bello, Michelle N Perry, and Cynthia Smith

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Genome-Based Targeted Sequencing as a Reproducible Microbial Community Profiling Assay., Jacquelynn Benjamino, Benjamin Leopold, Daniel S Phillips, and Mark D Adams

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Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and -independent phagosomal signals that contribute to phagocytosis and inflammation., Sarah J Benjamin, Kelly L Hawley, Paola Vera-Licona, Carson J La Vake, Jorge L Cervantes, Yijun Ruan, Justin D Radolf, and Juan C Salazar

Exploring mechanisms of protein influence on calcium oxalate kidney stone formation., Garrett K Berger, Jessica Eisenhauer, Andrew Vallejos, Brian Hoffmann, and Jeffrey A Wesson

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Functional impact of a germline RET mutation in alveolar rhabdomyosarcoma., Noah E Berlow, Kenneth A Crawford, Carol J Bult, Christopher Noakes, Ido Sloma, Erin R Rudzinski, and Charles Keller

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Novel phosphatidylserine-binding molecule enhances antitumor T-cell responses by targeting immunosuppressive exosomes in human tumor microenvironments., Maulasri Bhatta, Gautam N Shenoy, Jenni L Loyall, Brian D Gray, Meghana Bapardekar, Alexis Conway, Hans Minderman, Raymond J Kelleher, Beatriz M Carreno, Gerald Linette, Leonard D. Shultz, Kunle Odunsi, Sathy V Balu-Iyer, Koon Yan Pak, and Richard B Bankert

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A resource of targeted mutant mouse lines for 5,061 genes., Marie-Christine Birling, Atsushi Yoshiki, David J Adams, Shinya Ayabe, Arthur L Beaudet, Joanna Bottomley, Allan Bradley, Steve D M Brown, Antje Bürger, Wendy Bushell, Francesco Chiani, Hsian-Jean Genie Chin, Skevoulla Christou, Gemma F Codner, Francesco J DeMayo, Mary E Dickinson, Brendan Doe, Leah Rae Donahue, Martin D Fray, Alessia Gambadoro, Xiang Gao, Marina Gertsenstein, Alba Gomez-Segura, Leslie Goodwin, Jason D Heaney, Yann Hérault, Martin Hrabe de Angelis, Si-Tse Jiang, Monica J Justice, Petr Kasparek, Ruairidh E King, Ralf Kühn, Ho Lee, Young Jae Lee, Zhiwei Liu, K C Kent Lloyd, Isabel Lorenzo, Ann-Marie Mallon, Colin McKerlie, Terrence F Meehan, Violeta Munoz Fuentes, Stuart Newman, Lauryl M J Nutter, Goo Taeg Oh, Guillaume Pavlovic, Ramiro Ramirez-Solis, Barry Rosen, Edward J Ryder, Luis A Santos, Joel Schick, John R Seavitt, Radislav Sedlacek, Claudia Seisenberger, Je Kyung Seong, William C Skarnes, Tania Sorg, Karen P Steel, Masaru Tamura, Glauco P Tocchini-Valentini, Chi-Kuang Leo Wang, Hannah Wardle-Jones, Marie Wattenhofer-Donzé, Sara Wells, Michael V. Wiles, Brandon J Willis, Joshua A Wood, Wolfgang Wurst, Ying Xu, International Mouse Phenotyping Consortium IMPC, Lydia Teboul, and Stephen A. Murray

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The AGE Presents Introduction to Geroscience video lecture series., Alessandro Bitto, Mitchell B Lee, Cristal M Hill, Ron Korstanje, and Matt Kaeberlein

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Mouse Genome Database (MGD): Knowledgebase for mouse-human comparative biology., Judith A. Blake, Richard M. Baldarelli, James A. Kadin, Joel E Richardson, Cynthia Smith, Carol J Bult, and Mouse Genome Database Group

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Whole Ovary Immunofluorescence, Clearing, and Multiphoton Microscopy for Quantitative 3D Analysis of the Developing Ovarian Reserve in Mouse., Ruby Boateng, Nathaniel Boechat, Philipp P Henrich, and Ewelina Bolcun-Filas

Deep Learning-Based Segmentation and Quantification in Experimental Kidney Histopathology., Nassim Bouteldja, Barbara M Klinkhammer, Roman D Bülow, Patrick Droste, Simon W Otten, Saskia Freifrau von Stillfried, Julia Moellmann, Susan Sheehan, Ron Korstanje, Sylvia Menzel, Peter Bankhead, Matthias Mietsch, Charis Drummer, Michael Lehrke, Rafael Kramann, Jürgen Floege, Peter Boor, and Dorit Merhof

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System-Level Analysis of Alzheimer's Disease Prioritizes Candidate Genes for Neurodegeneration., Jeffrey L Brabec, Montana Kay Lara, Anna L. Tyler, and J Matthew Mahoney

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Developing Quality Workforce Training: Considerations for the Adult Learner., Kelly Brackett

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Staff Training in the Time of COVID-19, Kelly LaRue Brackett

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Aberrant type 1 immunity drives susceptibility to mucosal fungal infections., Timothy J Break, Vasileios Oikonomou, Nicolas Dutzan, Jigar V Desai, Marc Swidergall, Tilo Freiwald, Daniel Chauss, Oliver J Harrison, Julie Alejo, Drake W Williams, Stefania Pittaluga, Chyi-Chia R Lee, Nicolas Bouladoux, Muthulekha Swamydas, Kevin W Hoffman, Teresa Greenwell-Wild, Vincent M Bruno, Lindsey B Rosen, Wint Lwin, Andy Renteria, Sergio M Pontejo, John P Shannon, Ian A Myles, Peter Olbrich, Elise M N Ferré, Monica Schmitt, Daniel Martin, Daniel L Barber, Norma V Solis, Luigi D Notarangelo, David V. Serreze, Mitsuru Matsumoto, Heather D Hickman, Philip M Murphy, Mark S Anderson, Jean K Lim, Steven M Holland, Scott G Filler, Behdad Afzali, Yasmine Belkaid, Niki M Moutsopoulos, and Michail S Lionakis

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Rasa3 regulates stage-specific cell cycle progression in murine erythropoiesis., Elena C Brindley, Julien Papoin, Lauren Kennedy, Ray F. Robledo, Steven L. Ciciotte, Theodosia A Kalfa, Luanne L. Peters, and Lionel Blanc

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Immuno-transcriptomic profiling of extracranial pediatric solid malignancies., Andrew S Brohl, Sivasish Sindiri, Jun S Wei, David Milewski, Hsien-Chao Chou, Young K Song, Xinyu Wen, Jeetendra Kumar, Hue V Reardon, Uma S Mudunuri, Jack R Collins, Sushma Nagaraj, Vineela Gangalapudi, Manoj Tyagi, Yuelin J Zhu, Katherine E Masih, Marielle E Yohe, Jack F Shern, Yue Qi, Udayan Guha, Daniel Catchpoole, Rimas J Orentas, Igor B Kuznetsov, Nicolas J Llosa, John A Ligon, Brian K Turpin, Daniel G Leino, Shintaro Iwata, Irene L Andrulis, Jay S Wunder, Silvia R C Toledo, Paul S Meltzer, Ching C Lau, Beverly A Teicher, Heather Magnan, Marc Ladanyi, and Javed Khan

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HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions., Elspeth A Bruford, Cristina R Antonescu, Andrew J Carroll, Arul Chinnaiyan, Ian A Cree, Nicholas C P Cross, Raymond Dalgleish, Robert Peter Gale, Christine J Harrison, Rosalind J Hastings, Jean-Loup Huret, Bertil Johansson, Michelle Le Beau, Cristina Mecucci, Fredrik Mertens, Roel G W Verhaak, and Felix Mitelman

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Host genetic control of gut microbiome composition., Jason A. Bubier, Elissa J Chesler, and George M. Weinstock

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Inactive rhomboid proteins RHBDF1 and RHBDF2 (iRhoms): a decade of research in murine models., Lisa M. Burzenski, Benjamin E. Low, Vivek Kohar, Leonard D. Shultz, Michael V. Wiles, and Vishnu Hosur

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SFRP4 drives invasion in gastric cancer and is an early predictor of recurrence., Rita A Busuttil, Joshy George, Colin M House, Stephen Lade, Catherine Mitchell, Natasha S Di Costanzo, Sharon Pattison, Yu-Kuan Huang, Patrick Tan, Jae-Ho Cheong, Sun Young Rha, and Alex Boussioutas

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Accelerating functional gene discovery in osteoarthritis., Natalie C Butterfield, Katherine F Curry, Julia Steinberg, Hannah Dewhurst, Davide Komla-Ebri, Naila S Mannan, Anne-Tounsia Adoum, Victoria D Leitch, John G Logan, Julian A Waung, Elena Ghirardello, Lorraine Southam, Scott E Youlten, J Mark Wilkinson, Elizabeth A McAninch, Valerie E Vancollie, Fiona Kussy, Jacqueline K White, Christopher J Lelliott, David J Adams, Richard Jacques, Antonio C Bianco, Alan Boyde, Eleftheria Zeggini, Peter I Croucher, Graham R Williams, and J H Duncan Bassett

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Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE., Simone Caielli, Jacob Cardenas, Adriana Almeida de Jesus, Jeanine Baisch, Lynnette Walters, Jean Philippe Blanck, Preetha Balasubramanian, Cristy Stagnar, Marina Ohouo, Seunghee Hong, Lorien Nassi, Katie Stewart, Julie Fuller, Jinghua Gu, Jacques Banchereau, Tracey Wright, Raphaela Goldbach-Mansky, and Virginia Pascual

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Hyperglycemia cooperates with Tet2 heterozygosity to induce leukemia driven by proinflammatory cytokine-induced lncRNA Morrbid., Zhigang Cai, Xiaoyu Lu, Chi Zhang, Sai Nelanuthala, Fabiola Aguilera, Abigail Hadley, Baskar Ramdas, Fang Fang, Kenneth Nephew, Jonathan J Kotzin, Adam Williams, Jorge Henao-Mejia, Laura Haneline, and Reuben Kapur

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The Impact of Experiential Learning in Host-Pathogen Research on Medical Students' Interests and Attitudes towards Microbiology and Immunology., Jorge Cervantes and Bo-Young Hong

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Investigation of oral, gastric, and duodenal microbiota in patients with upper gastrointestinal symptoms., Jorge Cervantes, Majd Michael, Bo-Young Hong, Aden Springer, Hua Guo, Burgandy Mendoza, Mingtao Zeng, Olof Sundin, and Richard McCallum

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A Practical Guide to Metabolomics Software Development., Hui-Yin Chang, Sean M Colby, Xiuxia Du, Javier D Gomez, Maximilian J Helf, Katerina Kechris, Christine R Kirkpatrick, Shuzhao Li, Gary J Patti, Ryan S Renslow, Shankar Subramaniam, Mukesh Verma, Jianguo Xia, and Jamey D Young

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Flow cytometric identification of T fh 13 cells in mouse and human, Jennifer S Chen, Jessica D S Grassmann, Uthaman Gowthaman, Sam J Olyha, Tregony Simoneau, M Cecilia Berin, Stephanie C Eisenbarth, and Adam Williams

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A microfluidic approach to rescue ALS motor neuron degeneration using rapamycin., Phaneendra Chennampally, Ambreen Sayed-Zahid, Prabakaran Soundararajan, Jocelyn Sharp, Gregory A. Cox, Scott D Collins, and Rosemary L Smith

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epihet for intra-tumoral epigenetic heterogeneity analysis and visualization., Xiaowen Chen, Haitham Ashoor, Ryan Musich, Jiahui Wang, Mingsheng Zhang, Chao Zhang, Mingyang Lu, and Sheng Li

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iCSDB: an integrated database of CRISPR screens., Ahyoung Choi, Insu Jang, Heewon Han, Min-Seo Kim, Jinhyuk Choi, Jieun Lee, Sung-Yup Cho, Yukyung Jun, Charles Lee, Jaesang Kim, Byungwook Lee, and Sanghyuk Lee

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Somatostatin-expressing parafacial neurons are CO2/H+ sensitive and regulate baseline breathing., Colin M Cleary, Brenda M Milla, Fu-Shan Kuo, Shaun James, William F Flynn, Paul Robson, and Daniel K Mulkey

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The Gene Ontology resource: enriching a GOld mine., Gene Ontology Consortium, Judith A. Blake, Mary E. Dolan, Harold J. Drabkin, and David P. Hill

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The genetic basis of inter-individual variation in recovery from traumatic brain injury., Daniel Cortes and Martin Pera

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Diagnostics and correction of batch effects in large-scale proteomic studies: a tutorial., Jelena Čuklina, Chloe H Lee, Evan G Williams, Tatjana Sajic, Ben C Collins, María Rodríguez Martínez, Varun S Sharma, Fabian Wendt, Sandra Goetze, Gregory R Keele, Bernd Wollscheid, Ruedi Aebersold, and Patrick G A Pedrioli

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E2F6 initiates stable epigenetic silencing of germline genes during embryonic development., Thomas Dahlet, Matthias Truss, Ute Frede, Hala Al Adhami, Anaïs F Bardet, Michael Dumas, Judith Vallet, Johana Chicher, Philippe Hammann, Sarah Kottnik, Peter Hansen, Uschi Luz, Gonzalo Alvarez, Ghislain Auclair, Jochen Hecht, Peter N Robinson, Christian Hagemeier, and Michael Weber

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Interpretable prioritization of splice variants in diagnostic next-generation sequencing., Daniel Danis, Julius O B Jacobsen, Leigh Carmody, Michael Gargano, Julie A McMurry, Ayushi Hegde, Melissa A Haendel, Giorgio Valentini, Damian Smedley, and Peter N Robinson

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A MT-TL1 variant identified by whole exome sequencing in an individual with intellectual disability, epilepsy, and spastic tetraparesis., Elke de Boer, Charlotte W Ockeloen, Leslie Matalonga, Rita Horvath, Richard J Rodenburg, Marieke J H Coenen, Mirian Janssen, Dylan Henssen, Christian Gilissen, Wouter Steyaert, Ida Paramonov, Aurélien Trimouille, Tjitske Kleefstra, Alain Verloes, Lisenka E L M Vissers, Solve-RD Consortium, and Peter N Robinson

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Identification of the Adult Hematopoietic Liver as the Primary Reservoir for the Recruitment of Pro-regenerative Macrophages Required for Salamander Limb Regeneration., Ryan J Debuque, Andrew J Hart, Gabriela H Johnson, Nadia Rosenthal, and James W Godwin

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Characterizing Long COVID: Deep Phenotype of a Complex Condition., Rachel R Deer, Madeline A Rock, Nicole Vasilevsky, Leigh Carmody, Halie Rando, Alfred J Anzalone, Marc D Basson, Tellen D Bennett, Timothy Bergquist, Eilis A Boudreau, Carolyn T Bramante, James Brian Byrd, Tiffany J Callahan, Lauren E Chan, Haitao Chu, Christopher G Chute, Ben D Coleman, Hannah E Davis, Joel Gagnier, Casey S Greene, William B Hillegass, Ramakanth Kavuluru, Wesley D Kimble, Farrukh M Koraishy, Sebastian Köhler, Chen Liang, Feifan Liu, Hongfang Liu, Vithal Madhira, Charisse R Madlock-Brown, Nicolas Matentzoglu, Diego R Mazzotti, Julie A McMurry, Douglas S McNair, Richard A Moffitt, Teshamae S Monteith, Ann M Parker, Mallory A Perry, Emily Pfaff, Justin T Reese, Joel Saltz, Robert A Schuff, Anthony E Solomonides, Julian Solway, Heidi Spratt, Gary S Stein, Anupam A Sule, Umit Topaloglu, George D Vavougios, Liwei Wang, Melissa A Haendel, and Peter N Robinson

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Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia., Anne P de Groot, Yoriko Saito, Eiryo Kawakami, Mari Hashimoto, Yuki Aoki, Rintaro Ono, Ikuko Ogahara, Saera Fujiki, Akiko Kaneko, Kaori Sato, Hiroshi Kajita, Takashi Watanabe, Masatoshi Takagi, Daisuke Tomizawa, Katsuyoshi Koh, Mariko Eguchi, Eiichi Ishii, Osamu Ohara, Leonard D. Shultz, Shuki Mizutani, and Fumihiko Ishikawa

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Genetic background determines renal response to chronic lithium treatment in female mice., Theun de Groot, Rosalinda A. Doty, Lars Damen, Ruben Baumgarten, Steffi Bressers, Joline Kraak, Peter M T Deen, and Ron Korstanje

Studying Tumor Angiogenesis and Cancer Invasion in a Three-Dimensional Vascularized Breast Cancer Micro-Environment., Madhuri Dey, Bugra Ayan, Marina Yurieva, Derya Unutmaz, and Ibrahim T Ozbolat

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SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus., Mikail Dogan, Lina Kozhaya, Lindsey Placek, Courtney Gunter, Mesut Yigit, Rachel Hardy, Matthew Plassmeyer, Paige Coatney, Kimberleigh Lillard, Zaheer Bukhari, Michael Kleinberg, Chelsea Hayes, Moshe Arditi, Ellen Klapper, Noah Merin, Bruce Tsan-Tang Liang, Raavi Gupta, Oral Alpan, and Derya Unutmaz

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INFIMA leverages multi-omics model organism data to identify effector genes of human GWAS variants., Chenyang Dong, Shane P Simonett, Sunyoung Shin, Donnie S Stapleton, Kathryn L Schueler, Gary Churchill, Leina Lu, Xiaoxiao Liu, Fulai Jin, Yan Li, Alan D Attie, Mark P Keller, and Sündüz Keleş

Emergence of Resistance to Ceftazidime-Avibactam in a Pseudomonas aeruginosa Isolate Producing Derepressed, G L Drusano, Robert A Bonomo, Steven M Marshall, Laura J Rojas, Mark D Adams, Maria F Mojica, Barry N Kreiswirth, Liang Chen, Nino Mtchedlidze, Meredith Bacci, Michael Vicchiarelli, Jürgen B Bulitta, and Arnold Louie

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Cytokines That Serve as Embryokines in Cattle., Alan D Ealy, Savannah L Speckhart, and Lydia K Wooldridge

Generation and basic characterization of a gene-trap knockout mouse model of Scn2a with a substantial reduction of voltage-gated sodium channel Na, Muriel Eaton, Jingliang Zhang, Zhixiong Ma, Anthony C Park, Emma Lietzke, Chloé M Romero, Yushuang Liu, Emily R Coleman, Xiaoling Chen, Tiange Xiao, Zhefu Que, Shirong Lai, Jiaxiang Wu, Ji Hea Lee, Sophia Palant, Huynhvi P Nguyen, Zhuo Huang, William C Skarnes, Wendy A Koss, and Yang Yang

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Haplotype-resolved diverse human genomes and integrated analysis of structural variation., Peter Ebert, Peter A Audano, Qihui Zhu, Bernardo Rodriguez-Martin, David Porubsky, Marc Jan Bonder, Arvis Sulovari, Jana Ebler, Weichen Zhou, Rebecca Serra Mari, Feyza Yilmaz, Xuefang Zhao, PingHsun Hsieh, Joyce Lee, Sushant Kumar, Jiadong Lin, Tobias Rausch, Yu Chen, Jingwen Ren, Martin Santamarina, Wolfram Höps, Hufsah Ashraf, Nelson T Chuang, Xiaofei Yang, Katherine M Munson, Alexandra P Lewis, Susan Fairley, Luke J Tallon, Wayne E Clarke, Anna O Basile, Marta Byrska-Bishop, André Corvelo, Uday S Evani, Tsung-Yu Lu, Mark J P Chaisson, Junjie Chen, Chong Li, Harrison Brand, Aaron M Wenger, Maryam Ghareghani, William T Harvey, Benjamin Raeder, Patrick Hasenfeld, Allison A Regier, Haley J Abel, Ira M Hall, Paul Flicek, Oliver Stegle, Mark B Gerstein, Jose M C Tubio, Zepeng Mu, Yang I Li, Xinghua Shi, Alex R Hastie, Kai Ye, Zechen Chong, Ashley D Sanders, Michael C Zody, Michael E Talkowski, Ryan E Mills, Scott E Devine, Charles Lee, Jan O Korbel, Tobias Marschall, and Evan E Eichler

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Maximizing the potential of aggressive mouse tumor models in preclinical drug testing., M Tarek Elghetany, Jia-Min Ho, Lois Hew Shi-Qi, Sekar Karthik, Jack M F Su, Qi Lin, YuChen Du, Jianhe Shen, Wing-Yuk Chow, Ching C Lau, Adekunle Adesina, Angela Major, Anat Erdreich-Epstein, Kam-Man Hui, Xiao-Nan Li, and Wan-Yee Teo

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Estrogen regulates the expression of retinoic acid synthesis enzymes and binding proteins in mouse skin., Helen B Everts, Kathleen A Silva, Adriana N Schmidt, Susan Opalenik, F Jason Duncan, Lloyd E King, John P Sundberg, and David E Ong

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Whole-genome screen identifies diverse pathways that negatively regulate ciliogenesis., Marion Failler, Ariadna Giro-Perafita, Mikito Owa, Shalini Srivastava, Chi Yun, David J Kahler, Derya Unutmaz, Francisco J Esteva, Irma Sánchez, and Brian D Dynlacht

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A protocol for rapid and parallel isolation of myocytes and non-myocytes from multiple mouse hearts., Gabriella E Farrugia, Michael A McLellan, Kate L Weeks, Aya Matsumoto, Charles D Cohen, Crisdion Krstevski, Taylah L Gaynor, Adam C Parslow, Julie R McMullen, and Alexander R Pinto

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A Translational Model for Venous Thromboembolism: MicroRNA Expression in Hibernating Black Bears., Amanda Fazzalari, Giacomo Basadonna, Alper Kucukural, Kahraman Tanriverdi, Milka Koupenova, Natalie Pozzi, Jahnavi Kakuturu, Ann-Kristin U Friedrich, Ron Korstanje, Nicholas Fowler, Jerrold L Belant, Dean E Beyer, Marjory B Brooks, Eric W Dickson, Meghan Blackwood, Chris Mueller, J Alexander Palesty, Jane E Freedman, and Mitchell A Cahan

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Draft Genome Sequences of 27 Northern Maine Clinical Isolates., Larry Feinstein, Kendra Batchelder, Lydia Tilley, and Grace Stafford

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Differences in cancer patients' and clinicians' preferences for disclosure of uncertain genomic tumor testing results., Anny T Fenton, Eric C Anderson, Elizabeth Scharnetzki, Kate Reed, Emily A Edelman, Andrey Antov, Jens Rueter, Paul K J Han, and MCGI Working Group

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A validated integrated clinical and molecular glioblastoma long-term survival-predictive nomogram., Sherise D Ferguson, Tiffany R Hodges, Nazanin K Majd, Kristin Alfaro-Munoz, Wajd N Al-Holou, Dima Suki, John F de Groot, Gregory N Fuller, Lee Xue, Miao Li, Carmen Jacobs, Ganesh Rao, Rivka R Colen, Joanne Xiu, Roel G W Verhaak, David Spetzler, Mustafa Khasraw, Raymond Sawaya, James P Long, and Amy B Heimberger

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Cultivation of common bacterial species and strains from human skin, oral, and gut microbiota., Elizabeth Fleming, Victor Pabst, Zoe Scholar, Ruoyun Xiong, Anita Y Voigt, Wei Zhou, Amelia Hoyt, Rachel Hardy, Anna Peterson, Ryan Beach, Yvette Ondouah-Nzutchi, Jinhong Dong, Lucinda Bateman, Suzanne D Vernon, and Julia Oh

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Ex uno, plures-From One Tissue to Many Cells: A Review of Single-Cell Transcriptomics in Cardiovascular Biology., Elvira Forte, Michael A McLellan, Daniel A Skelly, and Nadia Rosenthal

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Type 2 MI induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart., Elvira Forte, Mona Panahi, Nicoleta Baxan, Fu Siong Ng, Joseph J Boyle, Jane Branca, Olivia Bedard, Muneer G. Hasham, Lindsay Benson, Sian E Harding, Nadia Rosenthal, and Susanne Sattler

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Cross-Priming Dendritic Cells Exacerbate Immunopathology After Ischemic Tissue Damage in the Heart., Elvira Forte, Bryant Perkins, Amalia Sintou, Harkaran S Kalkat, Angelos Papanikolaou, Catherine Jenkins, Mashael Alsubaie, Rasheda A Chowdhury, Theodore M Duffy, Daniel A Skelly, Jane Branca, Mohamed Bellahcene, Michael D Schneider, Sian E Harding, Milena B Furtado, Fu Siong Ng, Muneer G. Hasham, Nadia Rosenthal, and Susanne Sattler

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Response by Forte and Sattler to Letter Regarding Article, "Cross-Priming Dendritic Cells Exacerbate Immunopathology After Ischemic Tissue Damage in the Heart"., Elvira Forte and Susanne Sattler

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Targeted RNAseq assay incorporating unique molecular identifiers for improved quantification of gene expression signatures and transcribed mutation fraction in fixed tumor samples., Chunxiao Fu, Michal Marczyk, Michael Samuels, Alexander J Trevarton, Jiaxin Qu, Rosanna Lau, Lili Du, Todd Pappas, Bruno V Sinn, Rebekah E Gould, Lajos Pusztai, Christos Hatzis, and W Fraser Symmans

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Neurokinin B-Expressing Neurons of the Central Extended Amygdala Mediate Inhibitory Synaptic Input onto Melanin-Concentrating Hormone Neuron Subpopulations., Akie Fujita, Lily Zhong, Monica S Antony, Elizabeth Chamiec-Case, Laura E Mickelsen, Scott E Kanoski, William F Flynn, and Alexander C Jackson

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Targeting T cell metabolism for immunotherapy., Jie Gao, Yanbo Liu, Jian Wei, Linlan Jiang, Jianwen Mao, Chih-Hao Chang, and Duojiao Wu

Homeostasis and Defense at the Surface of the Eye. The Conjunctival Microbiota., Arnulfo Garza, Giancarlo Diaz, Marah Hamdan, Akaanksh Shetty, Bo-Young Hong, and Jorge Cervantes

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Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities., Carl M Gay, C Allison Stewart, Elizabeth M Park, Lixia Diao, Sarah M Groves, Simon Heeke, Barzin Y Nabet, Junya Fujimoto, Luisa M Solis, Wei Lu, Yuanxin Xi, Robert J Cardnell, Qi Wang, Giulia Fabbri, Kasey R Cargill, Natalie I Vokes, Kavya Ramkumar, Bingnan Zhang, Carminia M Della Corte, Paul Robson, Stephen G Swisher, Jack A Roth, Bonnie S Glisson, David S Shames, Ignacio I Wistuba, Jing Wang, Vito Quaranta, John Minna, John V Heymach, and Lauren Averett Byers

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Action detection using a neural network elucidates the genetics of mouse grooming behavior., Brian Q Geuther, Asaf Peer, Hao He, Gautam Sabnis, Vivek M. Philip, and Vivek Kumar

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Reactome and the Gene Ontology: Digital convergence of data resources., Benjamin M Good, Kimberly Van Auken, David P. Hill, Huaiyu Mi, Seth Carbon, James P Balhoff, Laurent-Philippe Albou, Paul D Thomas, Christopher J Mungall, Judith A. Blake, and Peter D'Eustachio

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Genetic mapping of renal glutathione suggests a novel regulatory locus on the murine X chromosome and overlap with hepatic glutathione regulation., Rebecca L Gould, Steven W Craig, Susan McClatchy, Gary A Churchill, and Robert Pazdro

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Quantitative trait mapping in Diversity Outbred mice identifies novel genomic regions associated with the hepatic glutathione redox system., Rebecca L Gould, Steven W Craig, Susan McClatchy, Gary A Churchill, and Robert Pazdro

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Hippocampal and thalamic afferents form distinct synaptic microcircuits in the mouse infralimbic frontal cortex., Kourtney Graham, Nelson Spruston, and Erik B Bloss

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Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network., Mathys Grapotte, Manu Saraswat, Chloé Bessière, Christophe Menichelli, Jordan A Ramilowski, Jessica Severin, Yoshihide Hayashizaki, Masayoshi Itoh, Michihira Tagami, Mitsuyoshi Murata, Miki Kojima-Ishiyama, Shohei Noma, Shuhei Noguchi, Takeya Kasukawa, Akira Hasegawa, Harukazu Suzuki, Hiromi Nishiyori-Sueki, Martin C Frith, FANTOM Consortium, Clément Chatelain, Piero Carninci, Michiel J L de Hoon, Wyeth W Wasserman, Laurent Bréhélin, Charles-Henri Lecellier, Judith A. Blake, and Carol J Bult

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Genome-wide functional screen of 3'UTR variants uncovers causal variants for human disease and evolution., Dustin Griesemer, James R Xue, Steven K Reilly, Jacob C Ulirsch, Kalki Kukreja, Joe R Davis, Masahiro Kanai, David K Yang, John C Butts, Mehmet H Guney, Jeremy Luban, Stephen B Montgomery, Hilary K Finucane, Carl D Novina, Ryan Tewhey, and Pardis C Sabeti