HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions.
Document Type
Article
Publication Date
11-2021
Publication Title
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Keywords
JGM
JAX Source
Leukemia 2021 Nov; 35(11):3040-3043
Volume
35
Issue
11
First Page
3040
Last Page
3043
ISSN
1476-5551
PMID
34615987
DOI
https://doi.org/10.1038/s41375-021-01436-6
Abstract
Gene fusions have been discussed in the scientific literature since they were first detected in cancer cells in the early 1980s. There is currently no standardized way to denote the genes involved in fusions, but in the majority of publications the gene symbols in question are listed either separated by a hyphen (-) or by a forward slash (/). Both types of designation suffer from important shortcomings. HGNC has worked with the scientific community to determine a new, instantly recognizable and unique separator-a double colon (::)-to be used in the description of fusion genes, and advocates its usage in all databases and articles describing gene fusions.
Recommended Citation
Bruford E,
Antonescu C,
Carroll A,
Chinnaiyan A,
Cree I,
Cross N,
Dalgleish R,
Gale R,
Harrison C,
Hastings R,
Huret J,
Johansson B,
Le Beau M,
Mecucci C,
Mertens F,
Verhaak R,
Mitelman F.
HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions. Leukemia 2021 Nov; 35(11):3040-3043