Document Type
Article
Publication Date
4-1-2021
Publication Title
JACC Basic Transl Sci
Keywords
JGM
JAX Source
JACC Basic Transl Sci 2021 Apr; 6(4):331-345
Volume
6
Issue
4
First Page
331
Last Page
345
ISSN
2452-302X
PMID
33681537
DOI
https://doi.org/10.1016/j.jacbts.2021.01.002
Abstract
There is ongoing debate as to whether cardiac complications of coronavirus disease-2019 (COVID-19) result from myocardial viral infection or are secondary to systemic inflammation and/or thrombosis. We provide evidence that cardiomyocytes are infected in patients with COVID-19 myocarditis and are susceptible to severe acute respiratory syndrome coronavirus 2. We establish an engineered heart tissue model of COVID-19 myocardial pathology, define mechanisms of viral pathogenesis, and demonstrate that cardiomyocyte severe acute respiratory syndrome coronavirus 2 infection results in contractile deficits, cytokine production, sarcomere disassembly, and cell death. These findings implicate direct infection of cardiomyocytes in the pathogenesis of COVID-19 myocardial pathology and provides a model system to study this emerging disease.
Recommended Citation
Bailey A,
Dmytrenko O,
Greenberg L,
Bredemeyer A,
Ma P,
Liu J,
Penna V,
Winkler E,
Sviben S,
Brooks E,
Nair A,
Heck K,
Rali A,
Simpson L,
Saririan M,
Hobohm D,
Stump W,
Fitzpatrick J,
Xie X,
Zhang X,
Shi P,
Hinson J,
Gi W,
Schmidt C,
Leuschner F,
Lin C,
Diamond M,
Greenberg M,
Lavine K.
SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis. JACC Basic Transl Sci 2021 Apr; 6(4):331-345