A Platform for Experimental Precision Medicine: The Extended BXD Mouse Family.
Document Type
Article
Publication Date
2021
Keywords
JMG
JAX Source
Cell Syst 2021; 12
ISSN
2405-4720
PMID
33472028
DOI
https://doi.org/10.1016/j.cels.2020.12.002
Abstract
The challenge of precision medicine is to model complex interactions among DNA variants, phenotypes, development, environments, and treatments. We address this challenge by expanding the BXD family of mice to 140 fully isogenic strains, creating a uniquely powerful model for precision medicine. This family segregates for 6 million common DNA variants-a level that exceeds many human populations. Because each member can be replicated, heritable traits can be mapped with high power and precision. Current BXD phenomes are unsurpassed in coverage and include much omics data and thousands of quantitative traits. BXDs can be extended by a single-generation cross to as many as 19,460 isogenic F1 progeny, and this extended BXD family is an effective platform for testing causal modeling and for predictive validation. BXDs are a unique core resource for the field of experimental precision medicine.
Recommended Citation
Ashbrook D,
Arends D,
Prins P,
Mulligan M,
Roy S,
Williams E,
Lutz C,
Valenzuela A,
Bohl C,
Ingels J,
McCarty M,
Centeno A,
Hager R,
Auwerx J,
Lu L,
Williams R.
A Platform for Experimental Precision Medicine: The Extended BXD Mouse Family. Cell Syst 2021; 12