Document Type

Article

Publication Date

7-19-2021

Publication Title

Nat Commun

JAX Source

Nat Commun 2021 Jul 19; 12(1):4385

Volume

12

Issue

1

First Page

4385

Last Page

4385

ISSN

2041-1723

PMID

34282143

DOI

https://doi.org/10.1038/s41467-021-24584-w

Abstract

As the capacity for generating large-scale molecular profiling data continues to grow, the ability to extract meaningful biological knowledge from it remains a limitation. Here, we describe the development of a new fixed repertoire of transcriptional modules, BloodGen3, that is designed to serve as a stable reusable framework for the analysis and interpretation of blood transcriptome data. The construction of this repertoire is based on co-clustering patterns observed across sixteen immunological and physiological states encompassing 985 blood transcriptome profiles. Interpretation is supported by customized resources, including module-level analysis workflows, fingerprint grid plot visualizations, interactive web applications and an extensive annotation framework comprising functional profiling reports and reference transcriptional profiles. Taken together, this well-characterized and well-supported transcriptional module repertoire can be employed for the interpretation and benchmarking of blood transcriptome profiles within and across patient cohorts. Blood transcriptome fingerprints for the 16 reference cohorts can be accessed interactively via: https://drinchai.shinyapps.io/BloodGen3Module/ .

Comments

This article is licensed under a Creative Commons Attribution 4.0 International License.

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