Targeting T cell metabolism for immunotherapy.
Document Type
Article
Publication Date
12-2021
Publication Title
Journal of leukocyte biology
Keywords
JMG
JAX Source
J Leukoc Biol 2021 Dec; 110(6):1081-1090
Volume
110
Issue
6
First Page
1081
Last Page
1090
ISSN
1938-3673
PMID
34779530
DOI
https://doi.org/10.1002/jlb.5mr0921-011r
Grant
CA034196
Abstract
T cells play an important role in antitumor immunity. Numbers and function of T cells are controlled by regulating the uptake and utilization of nutrients, and their antitumor activity can be promoted by targeting metabolic pathways. In this review, we highlight the relationship between metabolism and cellular function of T cells. Specifically, we emphasize the metabolic state of tumor-infiltrating T cells and review key pathways that affect the antitumor function of T cells. In the field of tumor immunotherapy, targeting T cell metabolism to enhance the immune response is a new therapeutic strategy for enhancing immunotherapy combined with traditional treatments.
Recommended Citation
Gao J,
Liu Y,
Wei J,
Jiang L,
Mao J,
Chang C,
Wu D.
Targeting T cell metabolism for immunotherapy. J Leukoc Biol 2021 Dec; 110(6):1081-1090