Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and -independent phagosomal signals that contribute to phagocytosis and inflammation.

Authors

Sarah J Benjamin
Kelly L Hawley
Paola Vera-Licona
Carson J La Vake
Jorge L Cervantes
Yijun Ruan, The Jackson LaboratoryFollow
Justin D Radolf
Juan C Salazar

Document Type

Article

Publication Date

5-17-2021

Publication Title

BMC immunology [electronic resource]

Keywords

JGM

JAX Source

BMC Immunol 2021 May 17; 22(1):32

Volume

22

Issue

1

First Page

32

Last Page

32

ISSN

1471-2172

PMID

34000990

DOI

https://doi.org/10.1186/s12865-021-00418-8

Abstract

BACKGROUND: Macrophages play prominent roles in bacteria recognition and clearance, including Borrelia burgdorferi (Bb), the Lyme disease spirochete. To elucidate mechanisms by which MyD88/TLR signaling enhances clearance of Bb by macrophages, we studied wildtype (WT) and MyD88

RESULTS: MyD88

CONCLUSION: Our findings show that MyD88 signaling enhances, but is not required, for bacterial uptake or phagosomal maturation and provide mechanistic insights into how MyD88-mediated phagosomal signaling enhances Bb uptake and clearance.

Comments

This is an open access article under the CC BY-NC-ND license.

Recommended Citation

Benjamin S, Hawley K, Vera-Licona P, La Vake C, Cervantes J, Ruan Y, Radolf J, Salazar J. Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and -independent phagosomal signals that contribute to phagocytosis and inflammation. BMC Immunol 2021 May 17; 22(1):32