Heritable variation in locomotion, reward sensitivity and impulsive behaviors in a genetically diverse inbred mouse panel.
Document Type
Article
Publication Date
11-2021
Publication Title
Genes, brain, and behavior
Keywords
JMG
JAX Source
Genes Brain Behav 2021 Nov; 20(8):e12773
Volume
20
Issue
8
First Page
12773
Last Page
12773
ISSN
1601-183X
PMID
34672075
DOI
https://doi.org/10.1111/gbb.12773
Grant
DA039841
Abstract
Drugs of abuse, including alcohol and stimulants like cocaine, produce effects that are subject to individual variability, and genetic variation accounts for at least a portion of those differences. Notably, research in both animal models and human subjects point toward reward sensitivity and impulsivity as being trait characteristics that predict relatively greater positive subjective responses to stimulant drugs. Here we describe use of the eight collaborative cross (CC) founder strains and 38 (reversal learning) or 10 (all other tests) CC strains to examine the heritability of reward sensitivity and impulsivity traits, as well as genetic correlations between these measures and existing addiction-related phenotypes. Strains were all tested for activity in an open field and reward sensitivity (intake of chocolate BOOST®). Mice were then divided into two counterbalanced groups and underwent reversal learning (impulsive action and waiting impulsivity) or delay discounting (impulsive choice). CC and founder mice show significant heritability for impulsive action, impulsive choice, waiting impulsivity, locomotor activity, and reward sensitivity, with each impulsive phenotype determined to be non-correlating, independent traits. This research was conducted within the broader, inter-laboratory effort of the Center for Systems Neurogenetics of Addiction (CSNA) to characterize CC and DO mice for multiple, cocaine abuse related traits. These data will facilitate the discovery of genetic correlations between predictive traits, which will then guide discovery of genes and genetic variants that contribute to addictive behaviors.
Recommended Citation
Bailey L,
Bagley J,
Dodd R,
Olson A,
Bolduc M,
Philip VM,
Reinholdt L,
Sukoff Rizzo S,
Tarantino L,
Gagnon LH,
Chesler E,
Jentsch J.
Heritable variation in locomotion, reward sensitivity and impulsive behaviors in a genetically diverse inbred mouse panel. Genes Brain Behav 2021 Nov; 20(8):e12773
Comments
We gratefully acknowledge the technical assistance of Ms. Barbara Force and the contribution of the Computational Sciences Service at The Jackson Laboratory for expert assistance with the work described in this publication.