Document Type

Article

Publication Date

10-19-2021

Publication Title

Cell Rep

Keywords

JMG

JAX Source

Cell Rep 2021 Oct 19; 37(3):109837

Volume

37

Issue

3

First Page

109837

Last Page

109837

ISSN

2211-1247

PMID

34686328

DOI

https://doi.org/10.1016/j.celrep.2021.109837

Abstract

The selection of goal-directed behaviors is supported by neural circuits located within the frontal cortex. Frontal cortical afferents arise from multiple brain areas, yet the cell-type-specific targeting of these inputs is unclear. Here, we use monosynaptic retrograde rabies mapping to examine the distribution of afferent neurons targeting distinct classes of local inhibitory interneurons and excitatory projection neurons in mouse infralimbic frontal cortex. Interneurons expressing parvalbumin, somatostatin, or vasoactive intestinal peptide receive a large proportion of inputs from the hippocampus, while interneurons expressing neuron-derived neurotrophic factor receive a large proportion of inputs from thalamic regions. A similar dichotomy is present among the four different excitatory projection neurons. These results show a prominent bias among long-range hippocampal and thalamic afferent systems in their targeting to specific sets of frontal cortical neurons. Moreover, they suggest the presence of two distinct local microcircuits that control how different inputs govern frontal cortical information processing.

Comments

This is an open access article under the CC BY-NC-ND license.

Download

Share

COinS