Allopregnanolone Improves Locomotor Activity and Arousal in the Aged CGG Knock-in Mouse Model of Fragile X-Associated Tremor/Ataxia Syndrome.

Authors

Jared J Schwartzer
Dolores Garcia-Arocena, The Jackson LaboratoryFollow
Amanda Jamal
Ali Izadi
Rob Willemsen
Robert F Berman

Document Type

Article

Publication Date

1-1-2021

Publication Title

Front Neurosci

Keywords

JAX Sacramento

JAX Source

Front Neurosci 2021 Dec 3; 15:752973

Volume

15

First Page

752973

Last Page

752973

ISSN

1662-4548

PMID

34924931

DOI

https://doi.org/10.3389/fnins.2021.752973

Abstract

Carriers of the fragile X premutation (PM) can develop a variety of early neurological symptoms, including depression, anxiety and cognitive impairment as well as being at risk for developing the late-onset fragile X-associated tremor/ataxia syndrome (FXTAS). The absence of effective treatments for FXTAS underscores the importance of developing efficacious therapies to reduce the neurological symptoms in elderly PM carriers and FXTAS patients. A recent preliminary study reported that weekly infusions of Allopregnanolone (Allop) may improve deficits in executive function, learning and memory in FXTAS patients. Based on this study we examined whether Allop would improve neurological function in the aged CGG knock-in (CGG KI) dutch mouse, B6.129P2(Cg)-Fmr1

Comments

This article is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Schwartzer J, Garcia-Arocena D, Jamal A, Izadi A, Willemsen R, Berman R. Allopregnanolone Improves Locomotor Activity and Arousal in the Aged CGG Knock-in Mouse Model of Fragile X-Associated Tremor/Ataxia Syndrome. Front Neurosci 2021 Dec 3; 15:752973