An in vivo screen of noncoding loci reveals that Daedalus is a gatekeeper of an Ikaros-dependent checkpoint during haematopoiesis.
Proc Natl Acad Sci U S A 2021 Jan 19; 118(2):e1918062118
Haematopoiesis relies on tightly controlled gene expression patterns as development proceeds through a series of progenitors. While the regulation of hematopoietic development has been well studied, the role of noncoding elements in this critical process is a developing field. In particular, the discovery of new regulators of lymphopoiesis could have important implications for our understanding of the adaptive immune system and disease. Here we elucidate how a noncoding element is capable of regulating a broadly expressed transcription factor, Ikaros, in a lymphoid lineage-specific manner, such that it imbues Ikaros with the ability to specify the lymphoid lineage over alternate fates. Deletion of the
Harman, Christian C D; Bailis, Will; Zhao, Jun; Hill, Louisa; Qu, Rihao; Jackson, Ruaidhrí P; Shyer, Justin A; Steach, Holly R; Kluger, Yuval; Goff, Loyal A; Rinn, John L; Williams, Adam; Henao-Mejia, Jorge; and Flavell, Richard A, "An in vivo screen of noncoding loci reveals that Daedalus is a gatekeeper of an Ikaros-dependent checkpoint during haematopoiesis." (2021). Faculty Research 2021. 31.