Title

An in vivo screen of noncoding loci reveals that Daedalus is a gatekeeper of an Ikaros-dependent checkpoint during haematopoiesis.

Document Type

Article

Publication Date

1-19-2021

Keywords

JGM

JAX Source

Proc Natl Acad Sci U S A 2021 Jan 19; 118(2):e1918062118

Volume

118

Issue

3

ISSN

1091-6490

PMID

33446502

DOI

https://doi.org/10.1073/pnas.1918062118

Abstract

Haematopoiesis relies on tightly controlled gene expression patterns as development proceeds through a series of progenitors. While the regulation of hematopoietic development has been well studied, the role of noncoding elements in this critical process is a developing field. In particular, the discovery of new regulators of lymphopoiesis could have important implications for our understanding of the adaptive immune system and disease. Here we elucidate how a noncoding element is capable of regulating a broadly expressed transcription factor, Ikaros, in a lymphoid lineage-specific manner, such that it imbues Ikaros with the ability to specify the lymphoid lineage over alternate fates. Deletion of the

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