Title
An in vivo screen of noncoding loci reveals that Daedalus is a gatekeeper of an Ikaros-dependent checkpoint during haematopoiesis.
Document Type
Article
Publication Date
1-19-2021
Keywords
JGM
JAX Source
Proc Natl Acad Sci U S A 2021 Jan 19; 118(2):e1918062118
Volume
118
Issue
3
ISSN
1091-6490
PMID
33446502
DOI
https://doi.org/10.1073/pnas.1918062118
Abstract
Haematopoiesis relies on tightly controlled gene expression patterns as development proceeds through a series of progenitors. While the regulation of hematopoietic development has been well studied, the role of noncoding elements in this critical process is a developing field. In particular, the discovery of new regulators of lymphopoiesis could have important implications for our understanding of the adaptive immune system and disease. Here we elucidate how a noncoding element is capable of regulating a broadly expressed transcription factor, Ikaros, in a lymphoid lineage-specific manner, such that it imbues Ikaros with the ability to specify the lymphoid lineage over alternate fates. Deletion of the
Recommended Citation
Harman C,
Bailis W,
Zhao J,
Hill L,
Qu R,
Jackson R,
Shyer J,
Steach H,
Kluger Y,
Goff L,
Rinn J,
Williams A,
Henao-Mejia J,
Flavell R.
An in vivo screen of noncoding loci reveals that Daedalus is a gatekeeper of an Ikaros-dependent checkpoint during haematopoiesis. Proc Natl Acad Sci U S A 2021 Jan 19; 118(2):e1918062118