The hyperpolarization-activated, cyclic nucleotide-gated channel resides on myocytes in mouse bladders and contributes to adrenergic-induced detrusor relaxation.

Document Type

Article

Publication Date

7-1-2022

Publication Title

American journal of physiology. Regulatory, integrative and comparative physiology

Keywords

JGM, Adrenergic Agents, Animals, Cyclic Nucleotide-Gated Cation Channels, Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels, Interstitial Cells of Cajal, Mice, Mice, Inbred C57BL, Nucleotides, Cyclic

JAX Source

Am J Physiol Regul Integr Comp Physiol 2022 Jul 1; 323(1):R110-R122

Volume

323

Issue

1

First Page

110

Last Page

110

ISSN

1522-1490

PMID

35503519

DOI

https://doi.org/10.1152/ajpregu.00277.2021

Abstract

Control of urinary continence is predicated on sensory signaling about bladder volume. Bladder sensory nerve activity is dependent on tension, implicating autonomic control over detrusor myocyte activity during bladder filling. Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels are known contributors to bladder control, but their mechanism of action is not well understood. The lack of a definitive identification of cell type(s) expressing HCN in the bladder presents a significant knowledge gap. We recently reported a complete transcriptomic atlas of the C57BL/6 mouse bladder showing the dominant HCN paralog in mouse bladder,

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