The hyperpolarization-activated, cyclic nucleotide-gated channel resides on myocytes in mouse bladders and contributes to adrenergic-induced detrusor relaxation.
American journal of physiology. Regulatory, integrative and comparative physiology
JGM, Adrenergic Agents, Animals, Cyclic Nucleotide-Gated Cation Channels, Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels, Interstitial Cells of Cajal, Mice, Mice, Inbred C57BL, Nucleotides, Cyclic
Am J Physiol Regul Integr Comp Physiol 2022 Jul 1; 323(1):R110-R122
Control of urinary continence is predicated on sensory signaling about bladder volume. Bladder sensory nerve activity is dependent on tension, implicating autonomic control over detrusor myocyte activity during bladder filling. Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels are known contributors to bladder control, but their mechanism of action is not well understood. The lack of a definitive identification of cell type(s) expressing HCN in the bladder presents a significant knowledge gap. We recently reported a complete transcriptomic atlas of the C57BL/6 mouse bladder showing the dominant HCN paralog in mouse bladder,
Lemtiri-Chlieh, Fouad; Baker, Dylan; Al-Naggar, Iman M; Ramasamy, Ramalakshmi; Kuchel, George A; Levine, Eric S; Robson, Paul; and Smith, Phillip P, "The hyperpolarization-activated, cyclic nucleotide-gated channel resides on myocytes in mouse bladders and contributes to adrenergic-induced detrusor relaxation." (2022). Faculty Research 2022. 111.