Document Type
Article
Publication Date
6-24-2022
Publication Title
Front Aging Neurosci
Keywords
JMG, JGM
Volume
14
First Page
886575
Last Page
886575
ISSN
1663-4365
PMID
35813947
DOI
https://doi.org/10.3389/fnagi.2022.886575
Grant
AG054345
Abstract
Obesity is recognized as a significant risk factor for Alzheimer's disease (AD). Studies have supported the notion that obesity accelerates AD-related pathophysiology in mouse models of AD. The majority of studies, to date, have focused on the use of early-onset AD models. Here, we evaluate the impact of genetic risk factors on late-onset AD (LOAD) in mice fed with a high fat/high sugar diet (HFD). We focused on three mouse models created through the IU/JAX/PITT MODEL-AD Center. These included a combined risk model with
Recommended Citation
Oblak A,
Kotredes K,
Pandey R,
Reagan A,
Ingraham C,
Perkins B,
Lloyd C,
Baker D,
Lin P,
Soni D,
Tsai A,
Persohn S,
Bedwell A,
Eldridge K,
Speedy R,
Meyer J,
Peters J,
Figueiredo L,
Sasner M,
Territo P,
Sukoff Rizzo S,
Carter GW,
Lamb B,
Howell G.
Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer's Disease-Relevant Phenotypes in Mice.
Comments
This is an open-access article distributed under the terms of the Creative Commons Attribution License