Front Aging Neurosci
Obesity is recognized as a significant risk factor for Alzheimer's disease (AD). Studies have supported the notion that obesity accelerates AD-related pathophysiology in mouse models of AD. The majority of studies, to date, have focused on the use of early-onset AD models. Here, we evaluate the impact of genetic risk factors on late-onset AD (LOAD) in mice fed with a high fat/high sugar diet (HFD). We focused on three mouse models created through the IU/JAX/PITT MODEL-AD Center. These included a combined risk model with
Oblak, Adrian L; Kotredes, Kevin P; Pandey, Ravi S; Reagan, Alaina M; Ingraham, Cynthia; Perkins, Bridget; Lloyd, Christopher; Baker, Deborah; Lin, Peter B; Soni, Disha M; Tsai, Andy P; Persohn, Scott A; Bedwell, Amanda A; Eldridge, Kierra; Speedy, Rachael; Meyer, Jill A; Peters, Johnathan S; Figueiredo, Lucas L; Sasner, Michael; Territo, Paul R; Sukoff Rizzo, Stacey J; Carter, Gregory W.; Lamb, Bruce T; and Howell, Gareth R, "Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer's Disease-Relevant Phenotypes in Mice." (2022). Faculty Research 2022. 149.