Biofabrication of 3D breast cancer models for dissecting the cytotoxic response of human T cells expressing engineered MAIT cell receptors.
Document Type
Article
Publication Date
9-29-2022
Publication Title
Biofabrication
Keywords
JGM, Breast Neoplasms, Cytokines, Female, Fibrin, Granzymes, Humans, Interferon-gamma, Interleukin-13, Ligands, Minor Histocompatibility Antigens, Mucosal-Associated Invariant T Cells, Receptors, Antigen, T-Cell, T-Lymphocytes, Tumor Microenvironment
JAX Source
Biofabrication. 2022;14(4):044105.
Volume
14
Issue
4
ISSN
1758-5090
PMID
36108605
DOI
https://doi.org/10.1088/1758-5090/ac925a
Grant
This work was supported by NSF Awards 1914885 (I T O) and 1624515 (I T O), 2236 CoCir- culation2 of TUBITAK Award 121C359 (I T O), and NIH Award R21 CA224422 01A1 (I T O and D U).
Abstract
Immunotherapy has revolutionized cancer treatment with the advent of advanced cell engineering techniques aimed at targeted therapy with reduced systemic toxicity. However, understanding the underlying immune-cancer interactions require development of advanced three-dimensional (3D) models of human tissues. In this study, we fabricated 3D tumor models with increasing complexity to study the cytotoxic responses of CD8
Recommended Citation
Dey M,
Kim M,
Nagamine M,
Karhan E,
Kozhaya L,
Dogan M,
Unutmaz D,
Ozbolat I.
Biofabrication of 3D breast cancer models for dissecting the cytotoxic response of human T cells expressing engineered MAIT cell receptors. Biofabrication. 2022;14(4):044105.