Document Type

Article

Publication Date

7-21-2022

Publication Title

Int J Mol Sci

Keywords

JGM, Adolescent, Biomarkers, Bone Neoplasms, Child, DNA, DNA Copy Number Variations, Gene Expression Regulation, Neoplastic, Humans, Insulin, Osteosarcoma, Prognosis, Receptor, IGF Type 1, Receptors, Growth Factor

JAX Source

Int J Mol Sci. 2022;23(14):8036

Volume

23

Issue

14

First Page

8036

ISSN

1422-0067

PMID

35887382

DOI

https://doi.org/10.3390/ijms23148036

Grant

This research was funded by NCI, grant number U01 CA114757-04.

Abstract

Osteosarcoma is a primary malignant bone tumor arising from bone-forming mesenchymal cells in children and adolescents. Despite efforts to understand the biology of the disease and identify novel therapeutics, the survival of osteosarcoma patients remains dismal. We have concurrently profiled the copy number and gene expression of 226 osteosarcoma samples as part of the Strategic Partnering to Evaluate Cancer Signatures (SPECS) initiative. Our results demonstrate the heterogeneous landscape of osteosarcoma in younger populations by showing the presence of genome-wide copy number abnormalities occurring both recurrently among samples and in a high frequency. Insulin growth factor receptor 1 (IGF1R) is a receptor tyrosine kinase which binds IGF1 and IGF2 to activate downstream pathways involved in cell apoptosis and proliferation. We identify prevalent amplification of IGF1R corresponding with increased gene expression in patients with poor survival outcomes. Our results substantiate previously tenuously associated copy number abnormalities identified in smaller datasets (13q34+, 20p13+, 4q35-, 20q13.33-), and indicate the significance of high fibroblast growth factor receptor 2 (FGFR2) expression in distinguishing patients with poor prognosis. FGFR2 is involved in cellular proliferation processes such as division, growth and angiogenesis. In summary, our findings demonstrate the prognostic significance of several genes associated with osteosarcoma pathogenesis.

Comments

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license

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