Document Type
Article
Publication Date
1-1-2022
Publication Title
Front Genet
Keywords
JMG
JAX Source
Front Genet. 2022;13:994501
Volume
13
First Page
994501
ISSN
1664-8021
PMID
36276935
DOI
https://doi.org/10.3389/fgene.2022.994501
Grant
This work was supported by grants from the National Institutes of Health DK074656 and AI56374 (CEM), DK36175 and DK27722 (EHL), as well as the American Diabetes Association.
Abstract
Alloxan (AL)-generated Reactive Oxygen Species (ROS) selectively destroy insulin-producing pancreatic β-cells. A previous genome-wide scan (GWS) using a cohort of 296 F2 hybrids between NOD (AL-sensitive) and ALR (AL-resistant) mice identified linkages contributing to β-cell susceptibility or resistance to AL-induced diabetes on Chromosomes (Chr) 2, 3, 8, and a single nucleotide polymorphism in
Recommended Citation
Chen J,
Li R,
Knapp S,
Zhu G,
Whitener R,
Leiter EH,
Mathews C.
Intergenomic and epistatic interactions control free radical mediated pancreatic β-cell damage. Front Genet. 2022;13:994501
Comments
This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY).