Front Genet. 2022;13:994501
This work was supported by grants from the National Institutes of Health DK074656 and AI56374 (CEM), DK36175 and DK27722 (EHL), as well as the American Diabetes Association.
Alloxan (AL)-generated Reactive Oxygen Species (ROS) selectively destroy insulin-producing pancreatic β-cells. A previous genome-wide scan (GWS) using a cohort of 296 F2 hybrids between NOD (AL-sensitive) and ALR (AL-resistant) mice identified linkages contributing to β-cell susceptibility or resistance to AL-induced diabetes on Chromosomes (Chr) 2, 3, 8, and a single nucleotide polymorphism in
Intergenomic and epistatic interactions control free radical mediated pancreatic β-cell damage. Front Genet. 2022;13:994501