Associations of the skin, oral and gut microbiome with aging, frailty and infection risk reservoirs in older adults.

Document Type

Article

Publication Date

10-1-2022

Publication Title

Nat Aging

Keywords

JGM

JAX Source

Nat Aging. 2022;2(10):941-55

Volume

2

Issue

10

First Page

941

Last Page

955

ISSN

2662-8465

PMID

36398033

DOI

https://doi.org/10.1038/s43587-022-00287-9

Grant

Funding for this project were provided by internal UConn support via the UConn Research Excellence Program and the UConn Microbiome Research Seed Grant. Investigator salaries were additionally supported by the National Institute on Aging (R56 AG060746 and P30 AG067988) and Claude D. Pepper Older Americans Independence Center at UConn. JO is additionally supported by the National Institutes of Health (DP2 GM126893-01, K22 AI119231-01, 1U54NS105539, 1 U19 AI142733 and 1 R21 AR075174), the National Science Foundation (1853071), the American Cancer Society, the Leo Foundation and the Mackenzie Foundation.

Abstract

Older adults represent a vulnerable population with elevated risk for numerous morbidities. To explore the association of the microbiome with aging and age-related susceptibilities including frailty and infectious disease risk, we conducted a longitudinal study of the skin, oral, and gut microbiota in 47 community- or skilled nursing facility-dwelling older adults vs. younger adults. We found that microbiome changes were not associated with chronological age so much as frailty: we identified prominent changes in microbiome features associated with susceptibility to pathogen colonization and disease risk, including diversity, stability, heterogeneity, and biogeographic determinism, which were moreover associated with a loss of

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